Vascular targeting agent-Combretastatin A4
文献类型：期刊论文
| 作者 | Ren X(任萱); Lin LP(林莉萍); Ding J(丁健)
|
| 刊名 | Chinese Journal New Drugs
 |
| 出版日期 | 2007 |
| 卷号 | 16期号:17页码:1336-1341 |
| 关键词 | Combertastatin A4 tumor vasculature antiangiogenic therapy vascular targeting agents Combretastatin A4 Combretastatin A4 phosphate(CA4P) |
| ISSN号 | 1003-3734 |
| 其他题名 | Combretastatin A4的抗肿瘤作用研究进展 |
| 文献子类 | Review |
| 英文摘要 | A growing solid tumor relies on a developing vasculature to meet its needs in terms of oxygen,nutrients and depuration,as well as providing a main route for metastatic spread.Tumor vasculature represents an appealing target for the development of new cancer treatments.Most of the research efforts have been focused on antiangiogenic therapy.However,recently there was increased interest in developing agents,which irreversibly damage the already formed neovasculature in tumors so called vascular targeting agents(VTAs).Many research focus on Combretastatin A4,one of the leading compound of the small molecular VTA for its remarkable anti-vascular effect in vitro and in vivo.Combretastatin A4 phosphate(CA4P),the water soluble prodrug of CA4 has been developmented by OxiGen. |
| 资助项目 | 国家自然科学基金面上项目(30572201)[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2933886 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268119]  |
| 专题 | 科研与新药推进处 药理学第一研究室 |
| 作者单位 | 中国科学院上海药物所, 新药研究国家重点实验室肿瘤药理组, 上海 201203, 中国. |
| 推荐引用方式 GB/T 7714 | Ren X,Lin LP,Ding J. Vascular targeting agent-Combretastatin A4[J]. Chinese Journal New Drugs,2007,16(17):1336-1341. |
| APA | 任萱,林莉萍,&丁健.(2007).Vascular targeting agent-Combretastatin A4.Chinese Journal New Drugs,16(17),1336-1341. |
| MLA | 任萱,et al."Vascular targeting agent-Combretastatin A4".Chinese Journal New Drugs 16.17(2007):1336-1341. |
入库方式： OAI收割
来源：上海药物研究所
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