Antitumor effects of vinflunine
文献类型：期刊论文
| 作者 | XIAO Liang1; QUAN Haitian2 ; XU Yongping2; TANG Weidong2; FU Li2; LOU Liguang2
|
| 刊名 | Chinese Pharmacological Bulletin
 |
| 出版日期 | 2007 |
| 卷号 | 23期号:4页码:507-511 |
| 关键词 | vinflunine microtubule assembly antitumor effect vinorelbine |
| ISSN号 | 1001-1978 |
| 其他题名 | 长春氟宁抗肿瘤作用的研究 |
| 文献子类 | Article |
| 英文摘要 | Aim To evaluate inhibitory effects of vinflunine on cellular microtubule assembly,and antitumor effects of vinflunine in vitro and in vivo. Methods Turbidity experiment was conducted to analyze the effects of vinflunine on microtubule assembly. Various tumor cell lines and mice implanted with different tumors were used to study anti-tumor effects of vinflunine in vitro and in vivo, respectively. Results Vinflunine inhibited microtubule assembly with an IC_(_50) value of 2.0 mumol·L~(-1). In vitro, vinflunine exhibited significant cytotoxicity on various tumor cell lines with IC_(50) values ranging from 0.05～2.2 mumol·L~(-1). In vivo vinflunine dose-dependently inhibited different tumor growth in mice. The potency of vinflunine was lower than that of vinorelbine in vitro and in vivo. However, at the dose of the strongest efficacy, vinflunine had more significant activity compared with vinorelbine. Conclusion Vinflunine inhibits cellular microtubule assembly and shows significant antitumor effects both in vivo and in vitro. |
| WOS研究方向 | General & Internal Medicine ; Oncology ; Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2786568 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268129]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | LOU Liguang |
| 作者单位 | 1.Shanghai Hengrui Pharmaceutical Co, LTD, Shanghai 200245, China.; 2.Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | XIAO Liang,QUAN Haitian,XU Yongping,et al. Antitumor effects of vinflunine[J]. Chinese Pharmacological Bulletin,2007,23(4):507-511. |
| APA | XIAO Liang,QUAN Haitian,XU Yongping,TANG Weidong,FU Li,&LOU Liguang.(2007).Antitumor effects of vinflunine.Chinese Pharmacological Bulletin,23(4),507-511. |
| MLA | XIAO Liang,et al."Antitumor effects of vinflunine".Chinese Pharmacological Bulletin 23.4(2007):507-511. |
入库方式： OAI收割
来源：上海药物研究所
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