Anti-tumor activity of Actinidia chinensis planch
文献类型：期刊论文
| 作者 | LOU Lijun1; Lu Dingliang1; HU Zengren1; ZHONG Songyang1; TANG Weidong2; XU Yongping2 |
| 刊名 | Chinese Pharmacological Bulletin
 |
| 出版日期 | 2007 |
| 卷号 | 23期号:6页码:808-811 |
| 关键词 | actinidia chinensis planch anti-tumor activity traditional Chinese medicine |
| ISSN号 | 1001-1978 |
| 其他题名 | 猕猴桃根抗肿瘤作用研究 |
| 文献子类 | Article |
| 英文摘要 | Aim To evaluate the anti-tumor activity of the extract from the root of Actinidia chinensis planch in vitro and in vivo. Methods Active components from the root of Actinidia chinensis planch were isolated by traditional phytochemical techniques. The in vitro anti-tumor activity was determined by sulforhodamine B assay and the in vivo anti-tumor activity was evaluated using experimental mouse tumor models and human tumor xenografts in nude mice. Results Powdered air-dried roots of Actinidia chinensis planch were percolated with methanol at room temperature thrice. The filtrate was concentrated to dryness in vacuo and then was further extracted with ethyl acetate, n-butanol , and chloroform. The fraction extracted by chloroform displayed the most potent activity against several tumor cell lines including hepatocellular carcinoma Bel-7402 cells, non-small cell lung cancer A549 cells, lymphoma Ramos cells, and breast cancer MCF-7 cells. Further more, the anti-tumor efficacy of the chloroform fraction was confirmed in Bel-7402 xenografts in nude mice with the percentage inhibition of 38.0 %. Conclusion The extract of the root of Actinidia chinensis planch has anti-tumor activity, and the active components are mainly in the fraction extracted by chloroform. |
| 资助项目 | 浙江省衢州市科委自然基金项目项目[00000000] |
| WOS研究方向 | General & Internal Medicine ; Oncology ; Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2830599 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268130]  |
| 专题 | 药理学第一研究室 |
| 作者单位 | 1.Quzhou People's Hospital, Quzhou, Zhejiang 324000, China.; 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | LOU Lijun,Lu Dingliang,HU Zengren,et al. Anti-tumor activity of Actinidia chinensis planch[J]. Chinese Pharmacological Bulletin,2007,23(6):808-811. |
| APA | LOU Lijun,Lu Dingliang,HU Zengren,ZHONG Songyang,TANG Weidong,&XU Yongping.(2007).Anti-tumor activity of Actinidia chinensis planch.Chinese Pharmacological Bulletin,23(6),808-811. |
| MLA | LOU Lijun,et al."Anti-tumor activity of Actinidia chinensis planch".Chinese Pharmacological Bulletin 23.6(2007):808-811. |
入库方式： OAI收割
来源：上海药物研究所
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