Effects and molecular mechanism of 5, 8-disubstituted quinazolines-LJK-11 in HER2 overexpressing cells
文献类型：期刊论文
| 作者 | QIN Lili2; JIN Yi1 ; LONG Yaqiu1; YU Qiang1; HE Jianyong2
|
| 刊名 | Journal of Shenyang Pharmaceutical University
 |
| 出版日期 | 2007 |
| 卷号 | 24期号:1页码:53 |
| 关键词 | LJK-11 HER2 LJK-11 tyrosine kinase inhibitor tumor HER2 cell death |
| ISSN号 | 1006-2858 |
| 其他题名 | 5，8-二代喹唑啉类化合物LJK-11对HER2高表达肿瘤细胞的作用和分子机制初探 |
| 文献子类 | Article |
| 英文摘要 | Objective To investigate the effects and molecular mechanism of LJK-11 on tumor cell. Methods The growth inhibition effects of LJK-11 on different tumor cell were measured by MTT assay. The effects on the expression and phosphorylation of HER2 were analyzed by western blot analysis. Results LJK-11 inhibited tumor cell growth in concentration-dependent manner. LJK-11 inhibited the phosphorylation of HER2.Conclusions LJK-11 may be developed as a novel kinase inhibitor. The inhibitory mechanism of LJK-11 provides a theoretical guidance for the development of novel anti-cancer agents. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2734119 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268146]  |
| 专题 | 药物安全性评价中心 药理学第一研究室 |
| 作者单位 | 1.Shanghai Institute of Medicine Research , Chinese Academic of Science, Shanghai 201203, China. 2.School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China.; |
| 推荐引用方式 GB/T 7714 | QIN Lili,JIN Yi,LONG Yaqiu,et al. Effects and molecular mechanism of 5, 8-disubstituted quinazolines-LJK-11 in HER2 overexpressing cells[J]. Journal of Shenyang Pharmaceutical University,2007,24(1):53. |
| APA | QIN Lili,JIN Yi,LONG Yaqiu,YU Qiang,&HE Jianyong.(2007).Effects and molecular mechanism of 5, 8-disubstituted quinazolines-LJK-11 in HER2 overexpressing cells.Journal of Shenyang Pharmaceutical University,24(1),53. |
| MLA | QIN Lili,et al."Effects and molecular mechanism of 5, 8-disubstituted quinazolines-LJK-11 in HER2 overexpressing cells".Journal of Shenyang Pharmaceutical University 24.1(2007):53. |
入库方式： OAI收割
来源：上海药物研究所
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