Tumor vascular targeting agents
文献类型：期刊论文
| 作者 | REN Xuan; SUN Qiming; LIN Liping; DING Jian
|
| 刊名 | Chinese Bulletin of Life Sciences
 |
| 出版日期 | 2007 |
| 卷号 | 19期号:4页码:427-432 |
| 关键词 | vascular targeting agents (VTAs) tumor angiogenensis inhibitors (TAIs) small molecule agents biological agents |
| ISSN号 | 1004-0374 |
| 其他题名 | 肿瘤血管靶向药物的研究进展 |
| 文献子类 | Review |
| 英文摘要 | The tumor vasculature plays a critical role in the survival and continued growth of solid tumor masses, which make it a valuable target for cancer therapy. Two pharmacological strategies invovled in this field were tumor angiogenensis inhibitors (TAIs) and vascular targeting agents (VTAs). The former aimed to inhibit the processes of neo-vasculature from the pre-existed tumor blood, the latter induce a rapid and selective vascular shutdown in tumors so that the blood flow is arrested and tumor cell dead due to the resulting oxygen and nutrient deprivation and buildup of waste products occurs. VTAs are divided into two main classes, small molecule agents and biological agents. The smalf molecule agents exploit the physiological differences between tumor and normal tissue endothelium to disrupt the tumor blood vessel selectively; the biological agents use a targeting ligand to achieve selectivity of binding to and occluding tumor vasculature. |
| 资助项目 | 国家自然科学基金面上项目(30572201)[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2912415 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268153]  |
| 专题 | 药理学第一研究室 |
| 作者单位 | State Key Laboratory of Drag Research, Shanghai Insititue of Meteria Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | REN Xuan,SUN Qiming,LIN Liping,et al. Tumor vascular targeting agents[J]. Chinese Bulletin of Life Sciences,2007,19(4):427-432. |
| APA | REN Xuan,SUN Qiming,LIN Liping,&DING Jian.(2007).Tumor vascular targeting agents.Chinese Bulletin of Life Sciences,19(4),427-432. |
| MLA | REN Xuan,et al."Tumor vascular targeting agents".Chinese Bulletin of Life Sciences 19.4(2007):427-432. |
入库方式： OAI收割
来源：上海药物研究所
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