Repair Pathways in Response to DNA Double-Strand Breaks
文献类型：期刊论文
| 作者 | Huang M(黄敏) ; Mou ZH(缪泽鸿); Ding J(丁健)
|
| 刊名 | Progress in Physiological Sciences
 |
| 出版日期 | 2007 |
| 卷号 | 38期号:4页码:295-300 |
| 关键词 | DNA double-strand breaks repair pathways homologous recombination repair non-homologous end joining |
| ISSN号 | 0559-7765 |
| 其他题名 | DNA双链断裂损伤修复系统研究进展 |
| 文献子类 | Review |
| 英文摘要 | DNA double-strand breaks (DSBs) are the principal cytotoxic lesions caused by many exogenous and endogenous factors. In response to DSBs, cells have evolved complex and highly conserved systems, which mainly consist of homologous recombination repair (HR) and non-homologous end joining (NHEJ) pathways, to effectively repair the lethal lesions. The two pathways play crucial roles in preserving the genomic integrity. Here, we provide an overview of detailed process, concerned molecules and regulatory factors in these pathways. Accumulated knowledge of DSBs repair may offer opportunities to develop more effective treatments for cancer. |
| 资助项目 | 中国科学院知识创新工程项目资助课题(KSX1-SW-11-6)[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2935023 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268156]  |
| 专题 | 药理学第一研究室 |
| 作者单位 | 中国科学院上海药物研究所, 国家新药研究重点实验室肿瘤药理组, 上海 201203, 中国. |
| 推荐引用方式 GB/T 7714 | Huang M,Mou ZH,Ding J. Repair Pathways in Response to DNA Double-Strand Breaks[J]. Progress in Physiological Sciences,2007,38(4):295-300. |
| APA | 黄敏,缪泽鸿,&丁健.(2007).Repair Pathways in Response to DNA Double-Strand Breaks.Progress in Physiological Sciences,38(4),295-300. |
| MLA | 黄敏,et al."Repair Pathways in Response to DNA Double-Strand Breaks".Progress in Physiological Sciences 38.4(2007):295-300. |
入库方式： OAI收割
来源：上海药物研究所
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