Pharmacokinetic characteristics of the active metabolites of magnesium lithospermate B in rats
文献类型：期刊论文
| 作者 | Wang Li1; Lu Youli1; Yang Ding1; Xue Zhimou2; Wang Yiping1
|
| 刊名 | Journal of Xi'an Jiaotong University. Medical Sciences
 |
| 出版日期 | 2007 |
| 卷号 | 28期号:4页码:395-398 |
| 关键词 | lithospermic acid B metabolite liquid chromatography/mass spectrometry rat pharmacokinetics |
| ISSN号 | 1671-8259 |
| 其他题名 | 丹参乙酸镁活性代谢产物在大鼠体内的药代动力学特征 |
| 文献子类 | Article |
| 英文摘要 | Objective To study the pharmacokinetics of two main metabolites of magnesium lithospermate B,3′-O-monomethyl-lithospermic acid B and 3′,3′′-O-dimethyl-lithospermic acid B,in Sprague-Dawley rats.Methods Serum was collected from rats at various times after animals were intravenously administered with M1 or M2,respectively.The analysis of M1 and M2 was performed in the MRM model by liquid chromatography/tandem mass spectrometry method and their pharmacokinetic parameters were calculated.Results In this method,the determination was not distracted by endogenous factors.Recovery of M1 and M2 was 87%-101.4%,intra-and inter-assay CVs were lower than 9.77%,LOQ was 1 mug/L(S/N≥3).Calibrations between 16-4 096 mug/L exhibited consistent linearity and reproducibility.The main parameters of pharmacokinetics of M1 and M2 were as follows: t1/2z of M1 and M2 was(1.540.81)h and(1.520.42)h,MRT(0-t) of M1 and M2 was(0.460.07)h and(0.330.05)h,AUC(0-tn) of M1 and M2 was(13.632.7)(mg·h)/L and(14.962.54)(mg·h)/L,respectively.Conclusion The pharmacokinetic characteristics of M1 and M2 by intravenous administration in rats is described by a two-compartment model. M1 and M2 were rapidly eliminated. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2979617 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268173]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Wang Yiping |
| 作者单位 | 1.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China.; 2.School of Life Sciences, Soochow University, Suzhou, Jiangsu 215006, China. |
| 推荐引用方式 GB/T 7714 | Wang Li,Lu Youli,Yang Ding,et al. Pharmacokinetic characteristics of the active metabolites of magnesium lithospermate B in rats[J]. Journal of Xi'an Jiaotong University. Medical Sciences,2007,28(4):395-398. |
| APA | Wang Li,Lu Youli,Yang Ding,Xue Zhimou,&Wang Yiping.(2007).Pharmacokinetic characteristics of the active metabolites of magnesium lithospermate B in rats.Journal of Xi'an Jiaotong University. Medical Sciences,28(4),395-398. |
| MLA | Wang Li,et al."Pharmacokinetic characteristics of the active metabolites of magnesium lithospermate B in rats".Journal of Xi'an Jiaotong University. Medical Sciences 28.4(2007):395-398. |
入库方式： OAI收割
来源：上海药物研究所
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