Advances in research of novel drugs based on S-adenosyl-L-homocysteine hydrolase as a potential target
文献类型：期刊论文
| 作者 | Fu Yufeng; Wu Qingli; Yang Yifu; Zuo Jianping
|
| 刊名 | Chinese Journal of Pharmacology and Toxicology
 |
| 出版日期 | 2006 |
| 卷号 | 20期号:6页码:510-514 |
| 关键词 | S-adenosyl-L-homocysteine hydrolase autoimmune diseases viruses atherosclerosis Alzheimer disease |
| ISSN号 | 1000-3002 |
| 其他题名 | 以S-腺苷同型半胱氨酸水解酶为潜在靶点的新药研究进展 |
| 文献子类 | Review |
| 英文摘要 | S-Adenosyl-L-homocysteine hydrolase (SAHH) is a ubiquitous enzyme catalyzing the hydrolysis of S-adenosyl-L-homocysteine (AdoHcy) to adenosine and homocysteine in mammalian cells. Inhibition of SAHH has been known to result in accumulation of intracellular levels of AdoHcy, which is a potent inhibitor of all 5-adenosyl-L-methionine-dependent transmethylation reactions. Based on the observation that mammalian cells appear to be. dependent on methyla-tion for activation, SAHH has recently been selected as an attractive specific target for design of agents for immunosuppression, antiviral, treatment of atherosclerosis and Alzheimer's disease. More and more researchers have focused their attention on SAHH inhibitors because of the original chemistry structure, potent efficacy, and unique mechanisms. |
| 资助项目 | 中科院知识创新项目[00000000] ; 国家自然科学基金资助项目[00000000] ; 上海科学技术委员会资助课题[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2638004 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268208]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Zuo Jianping |
| 作者单位 | Laboratory of Immunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Fu Yufeng,Wu Qingli,Yang Yifu,et al. Advances in research of novel drugs based on S-adenosyl-L-homocysteine hydrolase as a potential target[J]. Chinese Journal of Pharmacology and Toxicology,2006,20(6):510-514. |
| APA | Fu Yufeng,Wu Qingli,Yang Yifu,&Zuo Jianping.(2006).Advances in research of novel drugs based on S-adenosyl-L-homocysteine hydrolase as a potential target.Chinese Journal of Pharmacology and Toxicology,20(6),510-514. |
| MLA | Fu Yufeng,et al."Advances in research of novel drugs based on S-adenosyl-L-homocysteine hydrolase as a potential target".Chinese Journal of Pharmacology and Toxicology 20.6(2006):510-514. |
入库方式： OAI收割
来源：上海药物研究所
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