Platelet-derived growth factor receptor and cancer
文献类型：期刊论文
| 作者 | ZHANG XiuHua; LIN LiPing; DING Jian
|
| 刊名 | Chinese Bulletin of Life Sciences
 |
| 出版日期 | 2006 |
| 卷号 | 18期号:3页码:220-226 |
| 关键词 | platelet-derived growth factor platelet-derived growth factor receptor cancer therapy tyrosine kinase inhibitor |
| ISSN号 | 1004-0374 |
| 其他题名 | 血小板源生长因子受体与肿瘤 |
| 文献子类 | Review |
| 英文摘要 | Platelet-derived growth factors （PDGFs） exert their cellular effects through their receptors （PDGFRs）. PDGF and PDGFR have been implicated in the pathogenesis of a number of tumor types and play important roles in angiogenesis. Tumor growth can be promoted by PDGF via autocrine stimulation of malignant cells, overexpression or overactivation of PDGFRs, or stimulation of angiogenesis within the tumor. PDGFR blockade may also lower the interstitial fluid pressure within solid tumors and enhance drug delivery. These mechanisms suggest that PDGFR antagonists play possible and feasible therapeutic roles in the treatment of cancer, alone and in combination with chemotherapy or other targeting agents. Due to the success of PDGFR antagonist imatinib developments during the last years, the interests for PDGFRs as cancer drug targets will be dramatically improved. |
| 资助项目 | 973项目[00000000] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Oncology (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2451178 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268251]  |
| 专题 | 科研与新药推进处 药理学第一研究室 |
| 作者单位 | State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | ZHANG XiuHua,LIN LiPing,DING Jian. Platelet-derived growth factor receptor and cancer[J]. Chinese Bulletin of Life Sciences,2006,18(3):220-226. |
| APA | ZHANG XiuHua,LIN LiPing,&DING Jian.(2006).Platelet-derived growth factor receptor and cancer.Chinese Bulletin of Life Sciences,18(3),220-226. |
| MLA | ZHANG XiuHua,et al."Platelet-derived growth factor receptor and cancer".Chinese Bulletin of Life Sciences 18.3(2006):220-226. |
入库方式： OAI收割
来源：上海药物研究所
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