Telomere binding protein TRF2
文献类型：期刊论文
| 作者 | ZHANG YongWei; MIAO ZeHong; DING Jian
|
| 刊名 | Chinese Bulletin of Life Sciences
 |
| 出版日期 | 2006 |
| 卷号 | 18期号:3页码:239-243 |
| 关键词 | TRF2 telomere DNA damage response system |
| ISSN号 | 1004-0374 |
| 其他题名 | 端粒结合蛋白TRF2的研究进展 |
| 文献子类 | Review |
| 英文摘要 | TRF2 （TTAGGG repeat binding factor-2） is a telomere-related protein. Dimerized TRF2 proteins bind to the telomere repeat squence TTAGGG via their Myb motif. TRF2, TRF1, Rapl, TIN2, TINT1 as well as POT1 assemble a protein complex called shelterin and cooperate to play key roles in maintaining the homeostasis of telomeres. TRF2 not only functions on modeling telomere morphology, controlling telomere length and protecting 3＇ G-rich overhang, but also regulates the stability of genome. Beyond telomere, TRF2 could be involved in DNA damage response system when telomeric or non-telomeric DNA damage occurrs in cells. |
| 资助项目 | 国家自然科学基金[00000000] |
| WOS研究方向 | Biochemistry & Molecular Biology (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2451196 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268254]  |
| 专题 | 药理学第一研究室 |
| 作者单位 | State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | ZHANG YongWei,MIAO ZeHong,DING Jian. Telomere binding protein TRF2[J]. Chinese Bulletin of Life Sciences,2006,18(3):239-243. |
| APA | ZHANG YongWei,MIAO ZeHong,&DING Jian.(2006).Telomere binding protein TRF2.Chinese Bulletin of Life Sciences,18(3),239-243. |
| MLA | ZHANG YongWei,et al."Telomere binding protein TRF2".Chinese Bulletin of Life Sciences 18.3(2006):239-243. |
入库方式： OAI收割
来源：上海药物研究所
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