Determination of risperidone in human plasma by liquid chromatography-tandem mass spectrometry
文献类型：期刊论文
| 作者 | DUAN Xiaotao2; CHEN Xiaoyan1 ; ZHANG Yifan1; ZHONG Dafang1
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2006 |
| 卷号 | 41期号:7页码:684-688 |
| 关键词 | risperidone LC-MS/MS pharmacokinetics |
| ISSN号 | 0513-4870 |
| 其他题名 | 液相色谱-串联质谱法测定人血浆中的利培酮 |
| 文献子类 | Article |
| 英文摘要 | Aim To develop and validate a liquid chromatographic-tandem mass spectrometric （LCMS/MS） method for the determination of risperidone in human plasma. Methods Risperidone and the internal standard, diphenhydramine, were isolated from plasma by liquid-liquid extraction with etherdichloromethane （3：2,nu/nu） , then chromatographed on a Zorbax Extend-Cls column （150 mm * 4.6 mm ID, 5mum） using a mobile phase consisted of acetonitrile-water-formic acid （40： 60： 0.5, nu/nu） , at a flow rate of 0.7 mL · min ^-1 A Finnigan TSQ tandem mass spectrometer equipped with atmospheric pressure chemical ionization source was used as detector and was operated in the positive ion mode. Selected reaction monitoring （SRM） using the precursor product ion combinations of m/z 411191 and m/z 256167 were used to quantify risperidone and diphenhydramine （IS）, respectively. Results The linear concentration range of the calibration curve for risperidone was 0. 025 - 50 mug · L^-1. The lower limit of quantification was 0. 025 mug · L^-1. The intra - and inter-day relative standard deviation （RSD） across three validation running over the entire concentration range was less than 7.1%. The accuracy was within 3.8%. Each sample was chromatographed within 2.7 min. Conclusion The method was proved to be rapid, sensitive and suitable for pharmacokinetic investigations of risperidone. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2507706 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268272]  |
| 专题 | 上海药物代谢研究中心 |
| 通讯作者 | ZHONG Dafang |
| 作者单位 | 1.Center for Drug Metabolism Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. 2.Laboratory of Drug Metabolism and Pharmacokinetics, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China.; |
| 推荐引用方式 GB/T 7714 | DUAN Xiaotao,CHEN Xiaoyan,ZHANG Yifan,et al. Determination of risperidone in human plasma by liquid chromatography-tandem mass spectrometry[J]. Acta Pharmaceutica Sinica,2006,41(7):684-688. |
| APA | DUAN Xiaotao,CHEN Xiaoyan,ZHANG Yifan,&ZHONG Dafang.(2006).Determination of risperidone in human plasma by liquid chromatography-tandem mass spectrometry.Acta Pharmaceutica Sinica,41(7),684-688. |
| MLA | DUAN Xiaotao,et al."Determination of risperidone in human plasma by liquid chromatography-tandem mass spectrometry".Acta Pharmaceutica Sinica 41.7(2006):684-688. |
入库方式： OAI收割
来源：上海药物研究所
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