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The inhibition of CYP2C9 isoenzyme in Cunninghamellablakesleeana AS 3. 910

文献类型：期刊论文

作者LIN Lihong2; HUANG Haihua1; ZHANG Peng2; ZHONG Dafang3
刊名Acta Pharmaceutica Sinica
出版日期2006
卷号41期号:10页码:967-972
关键词cytochrome P-450 CYP2C9 Cunninghamella blakesleeana drug metabolism isoenzyme enzyme inhibitor
ISSN号0513-4870
其他题名短刺小克银汉霉AS3.910的CYP2C9同工酶抑制作用
文献子类Article
英文摘要Aim To investigate the variation of CYP2C9 isoenzyme activity in the microbial model in response to inhibitors of CYP2C9. Methods Using C. blakesleeana AS 3.910 as a model strain, the impact of CYP2C9 inhibitors on the metabolites yields of CYP2C9 substrates was determined and the drug-drug interactions among CYP2C9 substrates were evaluated. Liquid chromatography-mass spectrometry was used to analyze biotransformation products. Results Benzbromarone decreased the yield of 4'-hydroxytolbutamide from 100% to 14.5% ; sulfaphenazole decreased the yield of O-demethylindomethacin from 75.2% to 9.9%; valproic acid decreased the yield of 4'-hydroxydiclofenac from 98.6% to 2.7%, separately. Tolbutainide, indomethacin and diclofenac interacted with each other, resulting in the decreased formation of metabolites catalyzed by CYP2C9. Conclusion Three CYP2C9 inhibitors inhibit the activity of CYP2C9 isoenzyme in C. blakesleeana AS 3.910 differently, and there are drug-drug interactions among CYP2C9 substrates.
资助项目国家高技术研究发展计划资助项目[00000000]
WOS研究方向Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种中文
CSCD记录号CSCD:2420098
源URL[http://119.78.100.183/handle/2S10ELR8/268273]  
专题上海药物代谢研究中心
通讯作者ZHONG Dafang
作者单位1.Shanghai Drug-Melab Biotech Ltd., Shanghai 201204, China.;
2.Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China.;
3.Institute of Maleria Medina, Chinese Academy of Sciences, Shanghai 201203, China.
推荐引用方式
GB/T 7714		 LIN Lihong,HUANG Haihua,ZHANG Peng,et al. The inhibition of CYP2C9 isoenzyme in Cunninghamellablakesleeana AS 3. 910[J]. Acta Pharmaceutica Sinica,2006,41(10):967-972.
APA LIN Lihong,HUANG Haihua,ZHANG Peng,&ZHONG Dafang.(2006).The inhibition of CYP2C9 isoenzyme in Cunninghamellablakesleeana AS 3. 910.Acta Pharmaceutica Sinica,41(10),967-972.
MLA LIN Lihong,et al."The inhibition of CYP2C9 isoenzyme in Cunninghamellablakesleeana AS 3. 910".Acta Pharmaceutica Sinica 41.10(2006):967-972.

入库方式： OAI收割

来源：上海药物研究所

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