Enantiomeric separation of trimebutine, lafutidine and ondansetron by HPLC using chiral stationary phase
文献类型：期刊论文
| 作者 | DUAN Mingyu1; CHEN Xiaoyan2 ; ZHONG Dafang1
|
| 刊名 | Chinese Journal of Pharmaceutical Analysis
 |
| 出版日期 | 2006 |
| 卷号 | 26期号:9页码:1187-1191 |
| 关键词 | chiral stationary phase enantiomeric separation trimebutine lafutidine ondansetron liquid chromatography |
| ISSN号 | 0254-1793 |
| 其他题名 | 手性固定相色谱法直接拆分曲美布汀、拉呋替丁昂丹司琼对映异构体 |
| 文献子类 | Article |
| 英文摘要 | Objective：To develop chiral separation methods for the enantiomers of trimebutine,lafutidine and ondansetron. Method：Trimebutine ,lafutidine and ondansetron enantiomers were separated on vancomycin chiral stationary phase Chirobiotic V2（250 mm *4. 6 mm,5 mum）at a flow rate 1.0 mL· min-lat 20℃ ,chromatographic conditions were mobile phases consisted of methanol- glacial acetic acid- triethylamine （100： 0. 075： 0. 025 ） ,methanol- glacial acetic acid - triethylamine （ 100： 0. 025： 0. 075 ） and 20 mmol·L ^-1 ammonium acetate （ pH 4. 5 ） - methanol （50： 50）for separation of trimebutine enantiomers,lafutidine enantiomers and ondansetron enantiomers ,respectively. Ondansetron en- antiomers were separated on eq acid glycoprotein chiral stationary phase Chiral - AGP （ 150 mm * 4. 6 mm, 5mum ）, and chromatographic conditions were a mobile phase consisted of 20 mmol·L^-1 ammonium acetate （pH 4. 5 ） - acetonitrile（99. 8： 0. 2）at a flow rate 0. 9 mL·min^-1 at 15℃. Ondansetron enantiomers were separated on an ovomucoid chiral stationary phase Ultron ES - OVM （150 mm * 4.6 mm, 5mum）and chromatographic conditions were a mobile phase consisted of acetonitrile -water glacial acetic acid （2. 5： 97.5： 0. 0025 ） at a flow rate 0. 5 mL·min^-1 at 20℃. Results： Trimebutine, lafutidine and ondansetron enantiomers were separated on vancomycin chiral stationary phase and the resolutions were 2.75,3.58 and 0. 61, respectively. Ondansetron enantiomers were separated on alpha1- acid glycoprotein chiral chiral stationary phase with resolution of separated on vancomycin chiral stationary chiral stationary phase. stationary phase and the resolution was 1.26, but separated on ovomucoid 1.50. Conclusion： Trimebutine and lafutidine enantiomers can be full separated on vancomycin chiral stationary phase and ondansetron enantiomers can be full separated on ovomucoid chiral stationary phase. |
| 资助项目 | 国家863项目资助[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2577334 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268275]  |
| 专题 | 上海药物代谢研究中心 |
| 通讯作者 | ZHONG Dafang |
| 作者单位 | 1.Laboratory of Drug Metabolism and Pharmacokinetics, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China.; 2.Shanghai Institute of Matefia Medica,Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | DUAN Mingyu,CHEN Xiaoyan,ZHONG Dafang. Enantiomeric separation of trimebutine, lafutidine and ondansetron by HPLC using chiral stationary phase[J]. Chinese Journal of Pharmaceutical Analysis,2006,26(9):1187-1191. |
| APA | DUAN Mingyu,CHEN Xiaoyan,&ZHONG Dafang.(2006).Enantiomeric separation of trimebutine, lafutidine and ondansetron by HPLC using chiral stationary phase.Chinese Journal of Pharmaceutical Analysis,26(9),1187-1191. |
| MLA | DUAN Mingyu,et al."Enantiomeric separation of trimebutine, lafutidine and ondansetron by HPLC using chiral stationary phase".Chinese Journal of Pharmaceutical Analysis 26.9(2006):1187-1191. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。