Recent advance in the regulation of PTEN's function
文献类型：期刊论文
| 作者 | Liu Lunhua; Lou Liguang
|
| 刊名 | Chinese Pharmacological Bulletin
 |
| 出版日期 | 2005 |
| 卷号 | 21期号:7页码:778-781 |
| 关键词 | PTEN Akt PI3K PTEN Akl phosphatase phosphatidyli-nositol-3-kinase cancer suppressor gene |
| ISSN号 | 1001-1978 |
| 其他题名 | PTEN功能调节的研究进展 |
| 文献子类 | Review |
| 英文摘要 | The tumor suppressor PTEN is a dual-speci-ficity phosphatase possessing both protein phosphatase and lipid phosphatase activity. PTEN inhibits phos-phatidylinositol-3-kinase (PI3-K)/ Akt signaling path-way by dephosphorylaling phosphal:idylinosilol-( 3 , 4 , 5) -triphosphate at the 3 site. PTEN plays a pivotal role in cell growth, proliferation, migration, and apoptosis. The deregulation of PTEN has been implicated in a variety of human cancers such as prostate, endometrial, and breast cancers. Cellular PTEN's function appears to be regulated by its expression, phosphorylation, oxi-dation, and membrane binding. This review summa-rized the current progress in the molecular mechanism of PTEN's function. |
| 资助项目 | 国家自然科学基金资助项目[00000000] |
| WOS研究方向 | General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2094376 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268309]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Lou Liguang |
| 作者单位 | Shanghai Inslilule of Malaria Malica, Shanghai Intitules for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Liu Lunhua,Lou Liguang. Recent advance in the regulation of PTEN's function[J]. Chinese Pharmacological Bulletin,2005,21(7):778-781. |
| APA | Liu Lunhua,&Lou Liguang.(2005).Recent advance in the regulation of PTEN's function.Chinese Pharmacological Bulletin,21(7),778-781. |
| MLA | Liu Lunhua,et al."Recent advance in the regulation of PTEN's function".Chinese Pharmacological Bulletin 21.7(2005):778-781. |
入库方式： OAI收割
来源：上海药物研究所
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