Regulation of Tumor Suppressors Hamartin and Tuberin Signaling
文献类型：期刊论文
| 作者 | Zhao Wenyu; Lou Liguang
|
| 刊名 | Chinese Journal of Cell Biology
 |
| 出版日期 | 2005 |
| 卷号 | 27期号:5页码:489-492 |
| 关键词 | hamartin tuberin hamartin tuberin tumor suppressor |
| ISSN号 | 0253-9977 |
| 其他题名 | 肿瘤抑制因子Hamartin和Tuberin信号调控机制 |
| 文献子类 | Article |
| 英文摘要 | Tuberous sclerosis is an autosomal dominant disorder caused by mutations in tscl and tsc2 genes. Hamartin and tuberin, encoded by tscl and tsc2 genes, respectively, are tumor suppressors and play critical roles in cell growth and proliferation. Growth factor-stimulated PI3K/Akt signaling leads to tuberin phosphorylation, then regulates downstream effector function and affects cell growth and proliferation. This review summarizes the latest progresses in hamartin-and tuberin-mediated signaling transduction. We hope this review will give some insights into the understanding of the roles of hamartin and tuberin in cellular signaling and the challenge behind them. |
| WOS研究方向 | Cell Biology (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2032975 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268350]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Lou Liguang |
| 作者单位 | Shanghai Institute ofMateria Medica, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Zhao Wenyu,Lou Liguang. Regulation of Tumor Suppressors Hamartin and Tuberin Signaling[J]. Chinese Journal of Cell Biology,2005,27(5):489-492. |
| APA | Zhao Wenyu,&Lou Liguang.(2005).Regulation of Tumor Suppressors Hamartin and Tuberin Signaling.Chinese Journal of Cell Biology,27(5),489-492. |
| MLA | Zhao Wenyu,et al."Regulation of Tumor Suppressors Hamartin and Tuberin Signaling".Chinese Journal of Cell Biology 27.5(2005):489-492. |
入库方式： OAI收割
来源：上海药物研究所
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