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Inducing effect of resveratrol on anoikis of gastric cancer cells

文献类型：期刊论文

作者Li Ying1; Yao Libo1; Wang Lifeng1; Han Jiong1; Han Yueheng1; Liu Xinping1; Lin Shuxin2; Yu Qiang3
刊名Chinese Traditional and Herbal Drugs
出版日期2004
卷号35期号:10页码:1138-1140
关键词resveratrol anoikis gastric cancer cells
ISSN号0253-2670
其他题名白藜芦醇诱导胃癌细胞脱落凋亡
文献子类Article
英文摘要Object To study the inducing of resveratrol on anoikis of gastric cancer cells. Methods Cell morphology observation, Annxin-V and PI staining, and Flow cytometry (FCM) assay were used to observe the inducing effect of resveratrol (0. 1, 0. 2, 0. 5 mmol/L) on cell growth, cell cycles and anoikis of the gastric cancer cells (BGC823, SGC7901, and HGC27) cultured in suspension. Results Cluster growth of gastric cancer cells cultured in suspension was observed by invert microscope. Resveratrol (0. 1 mmol/L) could inhibit the gastric cancer cells resistant to anoikis to form cluster by FCM assay and Annx-in-V and PI staining. Resveratrol (0. 5 mmol/L) could arrest the suspended gastric cancer cells (BGC823, SGC7901, and HGC27) to G_o/G_1, S, G_2/M phase respectively and induce the gastric cancer cells to anoikis, and the anoikis rate of HGC27 was around 19. 3%, which was higher than that of other two cells. Conclusion Resveratrol can induce gastric cancer cells to anoikis.
资助项目国家自然科学基金[00000000] ; 军队"十五"科研基金重点课题[00000000]
WOS研究方向General & Internal Medicine (provided by Clarivate Analytics)
语种中文
CSCD记录号CSCD:1654282
源URL[http://119.78.100.183/handle/2S10ELR8/268387]  
专题药理学第一研究室
通讯作者Yu Qiang
作者单位1.Department of Biochemistry and Molecular Biology, Xian, Shanxi 710032, China.;
2.Department of Pathophysiology, Fourth Military Medical Univer-sity, Xian, Shanxi 710032, China.;
3.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
推荐引用方式
GB/T 7714		 Li Ying,Yao Libo,Wang Lifeng,et al. Inducing effect of resveratrol on anoikis of gastric cancer cells[J]. Chinese Traditional and Herbal Drugs,2004,35(10):1138-1140.
APA Li Ying.,Yao Libo.,Wang Lifeng.,Han Jiong.,Han Yueheng.,...&Yu Qiang.(2004).Inducing effect of resveratrol on anoikis of gastric cancer cells.Chinese Traditional and Herbal Drugs,35(10),1138-1140.
MLA Li Ying,et al."Inducing effect of resveratrol on anoikis of gastric cancer cells".Chinese Traditional and Herbal Drugs 35.10(2004):1138-1140.

入库方式： OAI收割

来源：上海药物研究所

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