Therapeutic opportunity in the transcriptional regulation of human mdr-1 gene
文献类型：期刊论文
| 作者 | Miao Zehong; Ding Jian
|
| 刊名 | Chinese Bulletin of Life Sciences
 |
| 出版日期 | 2004 |
| 卷号 | 16期号:4页码:200-205 |
| 关键词 | ET-743 tumor multidrug resistance mdr-1 gene transcriptional regulation Salvicine ET-743 |
| ISSN号 | 1004-0374 |
| 其他题名 | 多药耐药基因的转录调控与治疗学机会 |
| 文献子类 | Review |
| 英文摘要 | Transcription of human mdr-1 gene is complex and highly regulated. It involves the complicated interaction of numerous positive and negative elements with transcriptional factors and the epigenetic control as well. It is such complexity that determines the specific expression of mdr-1 expression in tissues and cells and its dependence on exogenous stimulators. This complexity is also the basis of selectively preventing or inhib-iting mdr-1 expression in tumor tissues and thus circumventing tumor multidrug resistance. Salvicine and ET-743, two novel anticancer drugs, uncovered the therapeutic opportunity hidden in the transcriptional regula-tion of human mdr-1 gene. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:1605741 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268406]  |
| 专题 | 药理学第一研究室 |
| 作者单位 | Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Miao Zehong,Ding Jian. Therapeutic opportunity in the transcriptional regulation of human mdr-1 gene[J]. Chinese Bulletin of Life Sciences,2004,16(4):200-205. |
| APA | Miao Zehong,&Ding Jian.(2004).Therapeutic opportunity in the transcriptional regulation of human mdr-1 gene.Chinese Bulletin of Life Sciences,16(4),200-205. |
| MLA | Miao Zehong,et al."Therapeutic opportunity in the transcriptional regulation of human mdr-1 gene".Chinese Bulletin of Life Sciences 16.4(2004):200-205. |
入库方式： OAI收割
来源：上海药物研究所
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