Effect of resveratrol derived from Rhizoma polygoni Cuspidati on apoptosis of gastric cancer cells HGC27
文献类型：期刊论文
| 作者 | Li Ying2; Yao Libo2; Wang Lifeng2; Han Jiong2; Han Yueheng2; Liu Xinping2; Lin Shuxin1; Yu Qiang3
|
| 刊名 | Journal of the Fourth Military Medical University
 |
| 出版日期 | 2004 |
| 卷号 | 25期号:19页码:1797-1799 |
| ISSN号 | 1000-2790 |
| 关键词 | HGC27 resveratrol apoptosis stomach neoplasm tumor cells HGC27 |
| 其他题名 | 虎仗提取物白藜芦醇诱导胃癌细胞HGC27凋亡 |
| 文献子类 | Article |
| 英文摘要 | AIM; To explore the inductive effects of the resveratrol from Rhizoma polygoni Cuspidati on the cell cycles, growth and apoptosis of the gastric cancer cells HGC27. METHODS: MTT method and soft agar assay were performed to observe the effects of the resveratrol on the cell growth. Annxin-V & PI staining assay and FCM assay were used to examine the inductive effects of resveratrol on the cell cycles and apoptosis. RESULTS: MTT results manifested that the cell survival rate decreased significantly and in dose dependent manner 24 h after HGC27 was incubated with 0. 5 mmol/L resveratrol ( P < 0. 01 vs control). Soft agar assay results indicated that HGC27 could not form cell colony when it was incubated with 0.5 mmol/L resveratrol. Annxin-V & PI staining assay and FCM assay showed that resveratrol could inhibit the HGC27 to Gl phase and induce cells to apoptosis (8.39%). CONCLUSION; Resveratrol can inhibit the growth of HGC27 and induce the cells to apoptosis. |
| 资助项目 | 国家自然科学基金[00000000] ; 军队"十五"科研基金重点课题[00000000] |
| WOS研究方向 | General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:1774337 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268416]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Yu Qiang |
| 作者单位 | 1.Department of Pathophysiology, School of Basic Medicine, Fourth Military Medi-cal University, Xian, Shanxi 710033, China.; 2.Department of Biochemistry & Molecular Biology, Fourth Military Medical University, Xian, Shanxi 710033, China.; 3.Shanghai Institute of Ma-teria Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Li Ying,Yao Libo,Wang Lifeng,et al. Effect of resveratrol derived from Rhizoma polygoni Cuspidati on apoptosis of gastric cancer cells HGC27[J]. Journal of the Fourth Military Medical University,2004,25(19):1797-1799. |
| APA | Li Ying.,Yao Libo.,Wang Lifeng.,Han Jiong.,Han Yueheng.,...&Yu Qiang.(2004).Effect of resveratrol derived from Rhizoma polygoni Cuspidati on apoptosis of gastric cancer cells HGC27.Journal of the Fourth Military Medical University,25(19),1797-1799. |
| MLA | Li Ying,et al."Effect of resveratrol derived from Rhizoma polygoni Cuspidati on apoptosis of gastric cancer cells HGC27".Journal of the Fourth Military Medical University 25.19(2004):1797-1799. |
入库方式： OAI收割
来源：上海药物研究所
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