Role of human liver and intestine esterases in drug design and development
文献类型：期刊论文
| 作者 | Jiang Jinfang; Li Xiuli; Chen Xiaoyan ; Zhong Dafang
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2018 |
| 卷号 | 53期号:2页码:177-185 |
| 关键词 | carboxylesterase arylacetamide deacetylase drug metabolism drug design |
| ISSN号 | 0513-4870 |
| 其他题名 | 肝脏和肠道酯酶在药物代谢及新药研发中的作用 |
| 文献子类 | Review |
| 英文摘要 | Human carboxylesterase (CES) and arylacetamide deacetylase (AADAC) are important numbers of the serine esterase superfamily. They are involved in hydrolytic procedure of human endogenous cholesteryl esters,as well as drug metabolism,activation and detoxication. They are closely related to the personalized medication of drugs,especially for prodrugs. This review summarizes their structure and distribution,metabolic characteristics and research progress in recent years,which will provide a reference for new drug development and rational drug design. |
| 资助项目 | 国家自然科学基金青年基金资助项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:6161106 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269178]  |
| 专题 | 上海药物代谢研究中心 |
| 通讯作者 | Zhong Dafang |
| 作者单位 | Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Jiang Jinfang,Li Xiuli,Chen Xiaoyan,et al. Role of human liver and intestine esterases in drug design and development[J]. Acta Pharmaceutica Sinica,2018,53(2):177-185. |
| APA | Jiang Jinfang,Li Xiuli,Chen Xiaoyan,&Zhong Dafang.(2018).Role of human liver and intestine esterases in drug design and development.Acta Pharmaceutica Sinica,53(2),177-185. |
| MLA | Jiang Jinfang,et al."Role of human liver and intestine esterases in drug design and development".Acta Pharmaceutica Sinica 53.2(2018):177-185. |
入库方式： OAI收割
来源：上海药物研究所
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