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Multi-compound pharmacokinetic research on Chinese herbal medicines: approach and methodology
文献类型：期刊论文
| 作者 | Li Chuan |
| 刊名 | China Journal of Chinese Materia Medica
 |
| 出版日期 | 2017 |
| 卷号 | 42期号:4页码:607-617 |
| 关键词 | multi-compound pharmacokinetic research Chinese herbal medicines pharmacokinetic markers for Chinese herbal medicines |
| ISSN号 | 1001-5302 |
| 其他题名 | 中药多成分药代动力学研究:思路与方法 |
| 文献子类 | Article |
| 英文摘要 | There are two prerequisites for the therapeutic action of a drug, i.e., having sufficient bioavailability to and biopersistence at the locus of action after dosing and having intrinsic ability to produce desired pharmacodynamic effects in their major exposure forms, unchanged and metabolized.As a special branch of pharmacology of Chinese herbal medicines, pharmacokinetics is to investigate issues related to the medicines' efficacy and safety by assessing the herbal ingredients' bioavailability to and biopersistence at the locus of action in the body.Chinese herbal medicines are often herb combinations of complex mixture and contain multiple bioactive ingredients working in concert.Unlike most investigational synthetic drugs developed from bench to bedside, Chinese herbal medicines are often developed from bedside to bench to bedside.Accordingly, pharmacokinetic research on Chinese herbal medicines could serve as a crucial step in identifying the chemical basis of the medicines' therapeutic actions and could facilitate development of new herbal medicines with enhanced efficacy and safety by using the right herbal ingredients in the right way.Mainly based on studies by the author's research group, this article illustrates approach to and methodology of multi-compound pharmacokinetic research on Chinese herbal medicines. |
| 资助项目 | 国家重点基础研究发展计划项目[00000000] ; 国家科技重大专项[00000000] ; 国家杰出青年科学基金项目[00000000] ; 上海市科技成果转化和产业化项目[00000000] |
| WOS研究方向 | General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5940852 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269213]  |
| 专题 | 上海药物代谢研究中心 科研与新药推进处 |
| 通讯作者 | Li Chuan |
| 作者单位 | State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Li Chuan. Multi-compound pharmacokinetic research on Chinese herbal medicines: approach and methodology[J]. China Journal of Chinese Materia Medica,2017,42(4):607-617. |
| APA | Li Chuan.(2017).Multi-compound pharmacokinetic research on Chinese herbal medicines: approach and methodology.China Journal of Chinese Materia Medica,42(4),607-617. |
| MLA | Li Chuan."Multi-compound pharmacokinetic research on Chinese herbal medicines: approach and methodology".China Journal of Chinese Materia Medica 42.4(2017):607-617. |
入库方式： OAI收割
来源：上海药物研究所
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