Determination of anaprazole in human plasma by LC-MS/MS in pharmacokinetic study
文献类型：期刊论文
| 作者 | Cheng Dongxia2; Dai Xiaojian3 ; Zhang Yifan3; Wu Yongqian1; Shi Chongtie1; Ma Xifeng1; Li Jin1; Chen Xiaoyan3; Zhong Dafang2
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2016 |
| 卷号 | 51期号:12页码:1885-1890 |
| 关键词 | LC-MS/MS anaprazole proton pump inhibitor clinical pharmacokinetics |
| ISSN号 | 0513-4870 |
| 其他题名 | LC-MS/MS法测定人血浆中的安纳拉唑及药动学初步应用 |
| 文献子类 | Article |
| 英文摘要 | Anaprazole is a proton pump inhibitor clinically used for curing peptic ulcer. A rapid, sensitive and convenient LC-MS/MS method was first established for the determination of anaprazole in human plasma. d_3, ~(13)C-anaprazole was used as internal standard (IS). After extraction from human plasma by protein precipitation with acetonitrile, all components were separated on an Extend C_(18) column (100 mm*4.6 mm, 3.5 mum). The assay was linear over the concentration range of 5.00-3 000 ng·mL~(-1) (r~2 > 0.995). The method was successfully applied to a pharmacokinetic study of 40 mg anaprazole enteric-coated tablets in 14 Chinese healthy volunteers under fasting or high fat diet conditions. C_(max) was (1 020435) ng·mL~(-1) and AUC_(0-t) was (2 370 754) h·ng·mL~(-1) under fasting condition. And C_(max) was (538 395) ng·mL~(-1) and AUC_(0-t) was (1 610 650) h·ng·mL~(-1) under high fat diet condition. The plasma results suggest that the exposure of anaprazole is reduced by the high fat diet. |
| 资助项目 | 重大新药创制科技重大专项资助项目[00000000] ; 中国科学院上海药物研究所新药研究国家重点实验室项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5870110 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269227]  |
| 专题 | 上海药物代谢研究中心 |
| 通讯作者 | Zhong Dafang |
| 作者单位 | 1.Xuan Zhu Pharma Co., Ltd., Ji'nan, Shandong 250100, China. 2.College of Pharmacy, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China.; 3.Shanghai Institute of Materia Medica, Shanghai 201203, China.; |
| 推荐引用方式 GB/T 7714 | Cheng Dongxia,Dai Xiaojian,Zhang Yifan,et al. Determination of anaprazole in human plasma by LC-MS/MS in pharmacokinetic study[J]. Acta Pharmaceutica Sinica,2016,51(12):1885-1890. |
| APA | Cheng Dongxia.,Dai Xiaojian.,Zhang Yifan.,Wu Yongqian.,Shi Chongtie.,...&Zhong Dafang.(2016).Determination of anaprazole in human plasma by LC-MS/MS in pharmacokinetic study.Acta Pharmaceutica Sinica,51(12),1885-1890. |
| MLA | Cheng Dongxia,et al."Determination of anaprazole in human plasma by LC-MS/MS in pharmacokinetic study".Acta Pharmaceutica Sinica 51.12(2016):1885-1890. |
入库方式： OAI收割
来源：上海药物研究所
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