Research Progress of Protein-based Chiral Stationary Phases and Their Applications to Chiral Drug Resolution
文献类型：期刊论文
| 作者 | Du Jiangbo; Chen Xiaoyan ; Zhong Dafang
|
| 刊名 | Chinese Journal of Pharmaceuticals
 |
| 出版日期 | 2015 |
| 卷号 | 46期号:10页码:1122-1130 |
| 关键词 | chiral stationary phase (CSP) protein-based CSP chiral drug resolution review |
| ISSN号 | 1001-8255 |
| 其他题名 | 蛋白质类手性固定相的研究进展及其在药物手性拆分中的应用 |
| 文献子类 | Review |
| 英文摘要 | Chromatographic resolution of chiral drugs includes three kinds of approaches, namely chiral derivatization approach, chiral mobile phase approach, and chiral stationary phase (CSP) approach. Along with the emerge of a large number of commercially available CSP columns, the CSP approach quickly dominates the field of chiral drug resolution, due to its various advantages of high speed, simplicity, and efficiency. Protein-based CSPs remain one of the most widely used CSPs, and exhibit enantioselectivity for a wide range of compounds because of multiple binding sites on the surface of chiral selectors and multiple binding interactions between chiral selectors and ligands. This review mainly focuses on the research progress of protein-based CSPs and their applications to chiral drug resolution in recent 3 years, with the emphasis on their enantioselective properties, application scope, the factors infl uencing drug resolution, and a chromatographic optimization scheme on these stationary phases. |
| WOS研究方向 | Chemistry (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5550604 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269267]  |
| 专题 | 上海药物代谢研究中心 |
| 通讯作者 | Zhong Dafang |
| 作者单位 | Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Du Jiangbo,Chen Xiaoyan,Zhong Dafang. Research Progress of Protein-based Chiral Stationary Phases and Their Applications to Chiral Drug Resolution[J]. Chinese Journal of Pharmaceuticals,2015,46(10):1122-1130. |
| APA | Du Jiangbo,Chen Xiaoyan,&Zhong Dafang.(2015).Research Progress of Protein-based Chiral Stationary Phases and Their Applications to Chiral Drug Resolution.Chinese Journal of Pharmaceuticals,46(10),1122-1130. |
| MLA | Du Jiangbo,et al."Research Progress of Protein-based Chiral Stationary Phases and Their Applications to Chiral Drug Resolution".Chinese Journal of Pharmaceuticals 46.10(2015):1122-1130. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。