Inhibition of lobaplatin on cultured human ovarian cancer cell proliferation in vitro
文献类型：期刊论文
| 作者 | Wei Jiangming2; Sheng Ye3; Sun Xu2; Lou Liguang1 ; Sui Donghu2
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| 刊名 | Chinese Journal of New Drugs and Clinical Remedies
 |
| 出版日期 | 2015 |
| 卷号 | 34期号:4页码:270-273 |
| 关键词 | lobaplatin ovarian neoplasms drug screening assays, antitumor in vitro |
| ISSN号 | 1007-7669 |
| 其他题名 | 洛铂对体外培养人卵巢癌细胞增殖的抑制作用 |
| 文献子类 | Article |
| 英文摘要 | AIM To observe the effects of lobaplatin (LBP) treatment on ovarian cancer cells in vitro. METHODS Seven kinds of human ovarian cancer cell lines SK-OV-3, ES-2, OVCAR-8,3AO, SW626, A2780,and OVCAR-3 were used to observe the anti- tumor effects of cisplatin (DDP),carboplatin (CBP), and LBP, alone or in combination with paclitaxel (PTX),docetaxel (TXT), on inhibition of human ovarian cancer cell proliferation in vitro. RESULTS LBP, DDP, CBP could significantly inhibit human ovarian carcinoma cells growth in vitro. IC_(50) of LBP was 1.5 - 13.8 mumol?L~(-1),DDP was 0.9 - 8.1 mumol?L~(-1),CBP was 14.6 - 145.7 mumol?L~(-1). When combining LBP, DDP, or CBP with PTX and TXT, the anti-tumor effect was cell - specific. LBP in combination with TXT showed additive effects in SK - OV - 3,OVCAR - 8 cells. CONCLUSION LBP has an obvious anti - human ovarian cancer cell proliferation activity, which is similar to DDP and better than CBP. LBP plus TXT has additive anti - tumor effects in certain ovarian cancer cells. |
| 资助项目 | 贵州省科技重大专项[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5412898 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269283]  |
| 专题 | 药理学第一研究室 |
| 作者单位 | 1.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. 2.Department of Medicine, Guizhou Yibai Pharmaceutical Co., Guiyang, Guizhou 550025, China.; 3.Department of Pharmcy,Liyang City People' s Hospital, Liyang, Jiangsu 213314, China.; |
| 推荐引用方式 GB/T 7714 | Wei Jiangming,Sheng Ye,Sun Xu,et al. Inhibition of lobaplatin on cultured human ovarian cancer cell proliferation in vitro[J]. Chinese Journal of New Drugs and Clinical Remedies,2015,34(4):270-273. |
| APA | Wei Jiangming,Sheng Ye,Sun Xu,Lou Liguang,&Sui Donghu.(2015).Inhibition of lobaplatin on cultured human ovarian cancer cell proliferation in vitro.Chinese Journal of New Drugs and Clinical Remedies,34(4),270-273. |
| MLA | Wei Jiangming,et al."Inhibition of lobaplatin on cultured human ovarian cancer cell proliferation in vitro".Chinese Journal of New Drugs and Clinical Remedies 34.4(2015):270-273. |
入库方式： OAI收割
来源：上海药物研究所
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