Progress in immunotherapy of sepsis
文献类型：期刊论文
| 作者 | Bai Bingxin1; Wu Yanwei2; Zhang Luyao2; Xue Lu1; Tang Wei2 ; Zuo Jianping1
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| 刊名 | Chinese Journal of New Drugs and Clinical Remedies
 |
| 出版日期 | 2015 |
| 卷号 | 34期号:3页码:161-166 |
| 关键词 | sepsis immune tolerance immunocompromised host inflammation cytokines targeted therapy |
| ISSN号 | 1007-7669 |
| 其他题名 | 脓毒症的免疫治疗进展 |
| 文献子类 | Review |
| 英文摘要 | Severe sepsis and septic shock are currently the main cause of death in intensive care unit patients. There are two competing views on the host immune response in severe sepsis. One side has argued that both the innate and the adaptive immune systems have entered a marked immunosuppressive state. Deaths have been due to an inability of the patients to clear primary infections and the development of secondary infections. Another competing view has claimed that the activation of innate immunity has been persistent in late sepsis. Late deaths have been due to organ injury caused by innate immune - driven inflammation. The correct therapies should be selected in clinical treatment according to the different stages and symptoms of disease onset. Recently, it has been shown that preparation against immune suppression, such as anti-PDl antibodies, human recombinant IL - 7, GM-CSF,and preparation targeting inflammatory cytokines including MIF, HMGB1 and C5a function very well on the animal models of sepsis and clinical trial. These preparations have brought new insight into targeting therapy of sepsis. |
| 资助项目 | 国家自然科学基金项目[00000000] ; 新药创制重大专项项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5389811 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269289]  |
| 专题 | 药理学第一研究室 |
| 作者单位 | 1.Laboratory of Immunology and Virology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.; 2.Laboratory of Immunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Bai Bingxin,Wu Yanwei,Zhang Luyao,et al. Progress in immunotherapy of sepsis[J]. Chinese Journal of New Drugs and Clinical Remedies,2015,34(3):161-166. |
| APA | Bai Bingxin,Wu Yanwei,Zhang Luyao,Xue Lu,Tang Wei,&Zuo Jianping.(2015).Progress in immunotherapy of sepsis.Chinese Journal of New Drugs and Clinical Remedies,34(3),161-166. |
| MLA | Bai Bingxin,et al."Progress in immunotherapy of sepsis".Chinese Journal of New Drugs and Clinical Remedies 34.3(2015):161-166. |
入库方式： OAI收割
来源：上海药物研究所
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