The enantioselective pharmacokinetic study of desvenlafaxine sustained release tablet in Chinese healthy male volunteers after oral administration
文献类型：期刊论文
| 作者 | Chen Yinxia1; Du Jiangbo2; Zhang Yifan2 ; Chen Xiaoyan2; Zhong Dafang1
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2015 |
| 卷号 | 50期号:4页码:486-491 |
| 关键词 | LC-MS/MS LC-MS/MS desvenlafaxine enantiomer pharmacokinetics |
| ISSN号 | 0513-4870 |
| 其他题名 | 中国男性健康志愿者口服去甲文拉法辛缓释片对映体选择性药动学研究 |
| 文献子类 | Article |
| 英文摘要 | A chiral LC-MS/MS method for the simultaneous analysis of desvenlafaxine (DVS)enantiomers in human plasma was developed and applied to a pharmacokinetic study on 12 Chinese healthy volunteers. d_6-Desvenlafaxine was used as internal standard (IS). Chromatographic separation was performed on the Astec Chirobiotic~(TM) V chiral column (150 mm * 4.6 mm, 5 mum). The assay was linear over the concentration range of 0.500-150 ng·mL~(-1) for both enantiomers (r~2 > 0.99). The method was successfully applied to a stereoselective pharmacokinetic study of 100 mg desvenlafaxine sustained release tablets on 12 Chinese healthy volunteers under fasting conditions. The results showed that the pharmacokinetic parameters were similar to both enantiomers in Chinese healthy volunteers. The AUC_(0-t) and C_(max) of the two enantiomers were about 1.5 times higher than those of blacks and whites reported in the literature. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5388148 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269291]  |
| 专题 | 上海药物代谢研究中心 |
| 通讯作者 | Zhong Dafang |
| 作者单位 | 1.College of Pharmacy, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China.; 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Chen Yinxia,Du Jiangbo,Zhang Yifan,et al. The enantioselective pharmacokinetic study of desvenlafaxine sustained release tablet in Chinese healthy male volunteers after oral administration[J]. Acta Pharmaceutica Sinica,2015,50(4):486-491. |
| APA | Chen Yinxia,Du Jiangbo,Zhang Yifan,Chen Xiaoyan,&Zhong Dafang.(2015).The enantioselective pharmacokinetic study of desvenlafaxine sustained release tablet in Chinese healthy male volunteers after oral administration.Acta Pharmaceutica Sinica,50(4),486-491. |
| MLA | Chen Yinxia,et al."The enantioselective pharmacokinetic study of desvenlafaxine sustained release tablet in Chinese healthy male volunteers after oral administration".Acta Pharmaceutica Sinica 50.4(2015):486-491. |
入库方式： OAI收割
来源：上海药物研究所
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