Predicting pharmacokinetics of anti-cancer drug, famitinib in human using physiologically based pharmacokinetic model
文献类型：期刊论文
| 作者 | Yu Mingming; Gao Zhiwei ; Chen Xiaoyan; Zhong Dafang
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2014 |
| 卷号 | 49期号:12页码:1684-1688 |
| 关键词 | famitinib physiologically based pharmacokinetic model species extrapolation tyrosine kinase inhibitor |
| ISSN号 | 0513-4870 |
| 其他题名 | 采用生理药动学模型预测抗肿瘤新药法米替尼在人体中的药动学 |
| 文献子类 | Article |
| 英文摘要 | This study is to establish physiologically based pharmacokinetic (PBPK) models of famitinib in rat and monkey, and then to predict the pharmacokinetics and tissue distribution of famitinib in human based on the PBPK models. According to published paper, previous studies and the chemical properties of famitinib predicted by ACD/ADME suite and SimCYP, the PBPK models of rat and monkey were established and optimized using GastroPlus. And then, the PBPK models were applied to predict the pharmacokinetic and tissue distribution of famitinib in human. The results showed that the PBPK models of rat and monkey can fit the observed data well, and the AUC_(0-) ratios of observed and calculated data in rat and monkey were 1.00 and 0.97, respectively. The AUC_(0-) ratios of observed and predicted data in human were 1.63 (rat to human) and 1.57 (monkey to human), respectively. The rat and monkey PBPK models of famitinib were well established, and the PBPK models were applied in predicting pharmacokinetic of famitinib in human successfully. Hence, the PBPK model of famitinib in human could be applied in future drug-drug interaction study. |
| 资助项目 | 国家"重大新药创制"科技重大专项[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5299734 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269306]  |
| 专题 | 上海药物代谢研究中心 |
| 通讯作者 | Zhong Dafang |
| 作者单位 | Center for Drug Metabolism and Pharmacokinetics Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Yu Mingming,Gao Zhiwei,Chen Xiaoyan,et al. Predicting pharmacokinetics of anti-cancer drug, famitinib in human using physiologically based pharmacokinetic model[J]. Acta Pharmaceutica Sinica,2014,49(12):1684-1688. |
| APA | Yu Mingming,Gao Zhiwei,Chen Xiaoyan,&Zhong Dafang.(2014).Predicting pharmacokinetics of anti-cancer drug, famitinib in human using physiologically based pharmacokinetic model.Acta Pharmaceutica Sinica,49(12),1684-1688. |
| MLA | Yu Mingming,et al."Predicting pharmacokinetics of anti-cancer drug, famitinib in human using physiologically based pharmacokinetic model".Acta Pharmaceutica Sinica 49.12(2014):1684-1688. |
入库方式： OAI收割
来源：上海药物研究所
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