Effects of efflux transporters on disposition of tyrosine kinase inhibitors
文献类型：期刊论文
| 作者 | Lin Lishan; Chen Xiaoyan ; Zhong Dafang
|
| 刊名 | Journal of International Pharmaceutical Research
 |
| 出版日期 | 2014 |
| 卷号 | 41期号:1页码:75-82 |
| ISSN号 | 1674-0440 |
| 关键词 | efflux transporter tyrosine kinase inhibitors disposition genetic polymorphism |
| 其他题名 | 外排转运体对酪氨酸激酶抑制剂体内处置过程的影响 |
| 文献子类 | Article |
| 英文摘要 | Oral tyrosine kinase inhibitors have been used for the treatment of cancers in recent years. Multiple tyrosine kinase inhibitors are substrates of ATP binding cassette transporter superfamily. The solubility of tyrosine kinase inhibitors is poor in gastrointestinal tract, and the efflux transporters are unlikely to be saturated. Therefore, compared with other drugs, absorption of these drugs is affected more significantly by efflux transporters. In addition, distribution and elimination of tyrosine kinase inhibitors are modulated by efflux transporters located in various tissues. In this review, how the efflux transporters modulate the disposition of seven tyrosine kinase inhibitors in vivo is summarized. The effect of genetic polymorphism of efflux transporters on the pharmacokinetics and pharmacology of these drugs is also reviewed. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5063172 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269350]  |
| 专题 | 上海药物代谢研究中心 |
| 通讯作者 | Zhong Dafang |
| 作者单位 | Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Lin Lishan,Chen Xiaoyan,Zhong Dafang. Effects of efflux transporters on disposition of tyrosine kinase inhibitors[J]. Journal of International Pharmaceutical Research,2014,41(1):75-82. |
| APA | Lin Lishan,Chen Xiaoyan,&Zhong Dafang.(2014).Effects of efflux transporters on disposition of tyrosine kinase inhibitors.Journal of International Pharmaceutical Research,41(1),75-82. |
| MLA | Lin Lishan,et al."Effects of efflux transporters on disposition of tyrosine kinase inhibitors".Journal of International Pharmaceutical Research 41.1(2014):75-82. |
入库方式： OAI收割
来源：上海药物研究所
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