Antiproliferative Activity of Phenylpropanoids Isolated from Lagotis brevituba Maxim
文献类型：期刊论文
| 作者 | Yuan Xiang2,3; Zhao Jing1 ; Wang Haixia2; Yu Ruitao2; Wen Huaixiu2,3; Liu Zenggen2; Mei Lijuan2; Wang Yiping1; Tao Yanduo2
|
| 刊名 | PHYTOTHERAPY RESEARCH
 |
| 出版日期 | 2017-10 |
| 卷号 | 31期号:10页码:1509-1520 |
| 关键词 | phenylpropanoids Lagotis brevituba Maxim antiproliferative plantamoside |
| ISSN号 | 0951-418X |
| DOI | 10.1002/ptr.5875 |
| 文献子类 | Article |
| 英文摘要 | The aim of the present study was to evaluate the antiproliferative effect of phenylpropanoids isolated from the n-BuOH-soluble fraction of an ethanolic extract of Lagotis brevituba Maxim. The phenylpropanoids were identified as echinacoside, lagotioside, glucopyranosyl(1-6)martynoside, plantamoside, and verbascoside. Three of the compounds, lagotioside, glucopyranosyl(1-6)martynoside, and plantamoside, were isolated from L. brevituba for the first time. The antiproliferative activity of the isolates was evaluated in human gastric carcinoma (MGC-803), human colorectal carcinoma (HCT116), human hepatocellar carcinoma (HepG2), and human lung cancer (HCT116) cells using an 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Plantamoside showed promising activity against MGC-803 cells, with a half maximal inhibitory concentration value of 37.09 mu M. The mechanism of the pro-apoptosis effect of plantamoside was then evaluated in MGC-803 cells. Changes in cell morphology, including disorganization of the architecture of actin microfilaments and formation of apoptotic bodies, together with cell cycle arrest in G2/M phases, were observed after treatment of plantamoside. The antiproliferative and pro-apoptotic effects were associated with a decrease in the ratio of Bcl-2/Bax and reduced mitochondrial membrane potential, which was accompanied by the release of reactive oxygen species and Ca2+ into the cytoplasm. Taken together, the results indicated that plantamoside promotes apoptosis via a mitochondria-dependent mechanism. Copyright (c) 2017 John Wiley & Sons, Ltd. |
| WOS关键词 | APOPTOSIS ; CELLS ; MITOCHONDRIA ; GLYCOSIDES ; CANCER ; FAMILY ; DEATH |
| 资助项目 | Chinese Academy of Sciences[ZSTH-027] ; Major Science and Technology Projects in Qinghai Province[2014-GX-A3A-01] ; Qinghai Association for Science and Technology[2017KX05] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000412164200005 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272471]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Wang Yiping; Tao Yanduo |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining 810001, Qinghai, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100000, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Yuan Xiang,Zhao Jing,Wang Haixia,et al. Antiproliferative Activity of Phenylpropanoids Isolated from Lagotis brevituba Maxim[J]. PHYTOTHERAPY RESEARCH,2017,31(10):1509-1520. |
| APA | Yuan Xiang.,Zhao Jing.,Wang Haixia.,Yu Ruitao.,Wen Huaixiu.,...&Tao Yanduo.(2017).Antiproliferative Activity of Phenylpropanoids Isolated from Lagotis brevituba Maxim.PHYTOTHERAPY RESEARCH,31(10),1509-1520. |
| MLA | Yuan Xiang,et al."Antiproliferative Activity of Phenylpropanoids Isolated from Lagotis brevituba Maxim".PHYTOTHERAPY RESEARCH 31.10(2017):1509-1520. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。