Synthesis and Anticancer Activity of cis-[Pt(II)(trans-1,2-bis(methylamino)cyclobutane) (3-hydroxyl-1,1-cyclobutanedicarboxylate)]
文献类型：期刊论文
| 作者 | Gao An-Li1; Qiu Jie3; Hou Shu-Qian1; Jiang Jing1; Lou Li-Guang2 ; Liu Wei-Ping1
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| 刊名 | CHINESE JOURNAL OF INORGANIC CHEMISTRY
 |
| 出版日期 | 2017-05-10 |
| 卷号 | 33期号:5页码:837-842 |
| 关键词 | platinum complexes synthesis characterization anticancer activity |
| ISSN号 | 1001-4861 |
| DOI | 10.11862/CJIC.2017.096 |
| 文献子类 | Article |
| 英文摘要 | A new water-soluble and more water-stable analogue of lobaplatin, cis-[Pt(II)(trans-1,2-bis(methylamino) cyclobutane)(3-hydroxyl-1,1-cyclobutanedicarboxylate)], was designed, with an attempt to improve the water-stability of lobaplatin while retaining its excellent anticancer profile, via the structural recombination and optimization of lobaplatin and carboplatin. The analogue was synthesized by the direct reaction between cis-[Pt(II)(trans-1,2-bis (methylamino))I-2 as an intermediate and the silver salt of 3-hydroxyl-1,1-cyclobutanedicarboxylic acid, and characterized by elemental analysis, ESI-MS, IR and H-1, C-13 NMR. The anticancer activity was evaluated by both in vitro cyotoxicity against four human cancer cell lines and in vivo antitumor efficiency in human lung carcinoma NCI-H460 xenografts in nude mice. The biological tests revealed that the analogue produced significant inhibition of the tumor growth, resulting in an inhibitory rate of 54% at the dose of 60 mg.kg (-1) and more importantly, it had in vivo anticancer activity comparable to that of lobaplatin. |
| WOS关键词 | PLATINUM COMPLEXES ; ANTITUMOR-ACTIVITY ; ANALOG ; HEPTAPLATIN ; TOXICITY ; DELIVERY ; AGENTS ; DRUGS |
| WOS研究方向 | Chemistry |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5987271 |
| WOS记录号 | WOS:000405542200015 |
| 出版者 | CHINESE CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272666]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Jiang Jing; Liu Wei-Ping |
| 作者单位 | 1.Kunming Inst Precious Met, Platinum Based Drug Lab, Kunming 650106, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Tumor PharmacologyLab, Shanghai 201203, Peoples R China 3.Lincang Maternal & Child Hlth Care Hosp, Lincang 677000, Yunnan, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Gao An-Li,Qiu Jie,Hou Shu-Qian,et al. Synthesis and Anticancer Activity of cis-[Pt(II)(trans-1,2-bis(methylamino)cyclobutane) (3-hydroxyl-1,1-cyclobutanedicarboxylate)][J]. CHINESE JOURNAL OF INORGANIC CHEMISTRY,2017,33(5):837-842. |
| APA | Gao An-Li,Qiu Jie,Hou Shu-Qian,Jiang Jing,Lou Li-Guang,&Liu Wei-Ping.(2017).Synthesis and Anticancer Activity of cis-[Pt(II)(trans-1,2-bis(methylamino)cyclobutane) (3-hydroxyl-1,1-cyclobutanedicarboxylate)].CHINESE JOURNAL OF INORGANIC CHEMISTRY,33(5),837-842. |
| MLA | Gao An-Li,et al."Synthesis and Anticancer Activity of cis-[Pt(II)(trans-1,2-bis(methylamino)cyclobutane) (3-hydroxyl-1,1-cyclobutanedicarboxylate)]".CHINESE JOURNAL OF INORGANIC CHEMISTRY 33.5(2017):837-842. |
入库方式： OAI收割
来源：上海药物研究所
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