Synthesis and anticancer activity of [2-hydroxy-1,3-diaminopropane-K-2 N,N '] platinum(II) complexes
文献类型：期刊论文
| 作者 | Liu, Weiping2; Chen, Xizhu2; Xie, Mingjin3; Lou, Liguang1 ; Ye, Qingsong2; Yu, Yao2; Hou, Shuqian2
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| 刊名 | JOURNAL OF INORGANIC BIOCHEMISTRY
 |
| 出版日期 | 2008-10 |
| 卷号 | 102期号:10页码:1942-1946 |
| 关键词 | platinum complexes peripheral functional group HO- synthesis structure anti-tumor |
| ISSN号 | 0162-0134 |
| DOI | 10.1016/j.jinorgbio.2008.07.003 |
| 文献子类 | Article |
| 英文摘要 | A series of novel platinum(II) complexes involving a carrier with HO- peripheral functional group, 2-hydroxy-1,3-propanediamine (HO-pda), cis-[Pt(HO-dpa)X-2] (X-2 = 2Cl(-) (1), C2O42- (2), malonate (3), 1,1-cyclobutane dicarboxylate (CBDCA) (4), 3-hydroxy-1,1-cyclobutanedicarboxylate (HO-CBDCA) (5)), have been synthesized and characterized by elemental analysis and spectroscopic data along with X-ray diffraction for three representative complexes 1, 4 and 5. The Pt(II) is in a square planar environment and is coordinated in cis position by a chelating HO-pda and 2Cl(-) for 1 and CBDCA for 4 and 5. Pt-N, Pt-Cl and Pt-O distances and coordinate bond angles of N-Pt-N, Cl-Pt-Cl and O-Pt-O are in the normal range. There are two independent molecules in the asymmetric unit of 5, held together by intermolecular hydrogen bonded chain. All the complexes show significant cytotoxicity on the sensitive cell lines SGC-7901, LNcap and A549, and are more active than carboplatin. 4 is also found to be active against the resistant cell A549/ATCC, which suggests that it has less cross-resistance with cisplatin than carboplatin. Moreover 4 shows much greater inhibition of tumor growth than carboplatin in S180-bearing mice, and is therefore worthy of further development as a potential anti-tumor platinum drug. (c) 2008 Elsevier Inc. All rights reserved. |
| WOS关键词 | DESIGN STRATEGIES ; CARRIER ; AGENTS ; CYTOTOXICITY ; PERSPECTIVES |
| 资助项目 | Yunnan Provincial Science Foundation of PR China[2006C0070M] ; Yunnan Provincial Science Foundation of PR China[2008C002M] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000259385700013 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272794]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Liu, Weiping |
| 作者单位 | 1.CAS, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Kunming Inst Precious Met, Platinum Based Drug Lab, Kunming 650106, Peoples R China; 3.Yunan Univ, Sch Chem, Yunan 650031, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Liu, Weiping,Chen, Xizhu,Xie, Mingjin,et al. Synthesis and anticancer activity of [2-hydroxy-1,3-diaminopropane-K-2 N,N '] platinum(II) complexes[J]. JOURNAL OF INORGANIC BIOCHEMISTRY,2008,102(10):1942-1946. |
| APA | Liu, Weiping.,Chen, Xizhu.,Xie, Mingjin.,Lou, Liguang.,Ye, Qingsong.,...&Hou, Shuqian.(2008).Synthesis and anticancer activity of [2-hydroxy-1,3-diaminopropane-K-2 N,N '] platinum(II) complexes.JOURNAL OF INORGANIC BIOCHEMISTRY,102(10),1942-1946. |
| MLA | Liu, Weiping,et al."Synthesis and anticancer activity of [2-hydroxy-1,3-diaminopropane-K-2 N,N '] platinum(II) complexes".JOURNAL OF INORGANIC BIOCHEMISTRY 102.10(2008):1942-1946. |
入库方式： OAI收割
来源：上海药物研究所
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