Antidiabetic effect of a novel non-thiazolidinedione PPAR gamma/alpha agonist on ob/ob mice
文献类型：期刊论文
| 作者 | Hu, Xi; Feng, Ying; Shen, Yu; Zhao, Xiao-feng; Yu, Juan-hong; Yang, Yu-she ; Leng, Ying
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2006-10 |
| 卷号 | 27期号:10页码:1346-1352 |
| 关键词 | diabetes insulin-sensitizing peroxisome proliferator-activated receptors thiazolidinediones |
| ISSN号 | 1671-4083 |
| DOI | 10.1111/j.1745-7245.2006.00427.x |
| 文献子类 | Article |
| 英文摘要 | Aim: To study whether T33, a new synthesized non-thiazolidinedione (TZD) peroxisome proliferator-activated receptor (PPAR) gamma/alpha dual agonist has an antidiabetic effect on ob/ob mice. Methods: Ob/ob mice were treated with 4 mg/kg or 8 mg/kg T33 by gavage for 20 d. Blood glucose levels were measured regularly. An oral glucose tolerance test (OGTT) and an insulin tolerance test (ITT) were preformed on d 8 and d 12, respectively. The levels of insulin, triglyceride and free fatty acid (FFA) in the serum were measured at the end of administration. The intramuscular and liver triglyceride content was also determined. Results: T33 reduced the hyperglycemia, hyperinsulinemia and hyperlipidemia of the ob/ob mice. The OGTT and ITT showed that the insulin resistance state of the ob/ob mice was obviously ameliorated after T33 treatment. After 20 d treatment with 8 mg/kg T33, the triglyceride content in the gastrocnemius muscle decreased significantly. T33 did not have any effect on triglyceride content in the liver, whereas rosiglitazone significantly increased the hepatocyte lipid deposition. Conclusion: The PPAR gamma/alpha dual agonist T33 has antidiabetic and insulin-sensitizing effects in ob/ob mice. It has the potential to be a new therapeutic candidate for the treatment of type 2 diabetes. |
| WOS关键词 | PROLIFERATOR-ACTIVATED RECEPTORS ; INSULIN-RESISTANCE ; SKELETAL-MUSCLE ; GAMMA AGONIST ; LIPID-METABOLISM ; ADIPOSE-TISSUE ; GLUCOSE ; ALPHA ; ROSIGLITAZONE ; SENSITIZER |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:2429049 |
| WOS记录号 | WOS:000240685400009 |
| 出版者 | BLACKWELL PUBLISHING |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273474]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Leng, Ying |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Xi,Feng, Ying,Shen, Yu,et al. Antidiabetic effect of a novel non-thiazolidinedione PPAR gamma/alpha agonist on ob/ob mice[J]. ACTA PHARMACOLOGICA SINICA,2006,27(10):1346-1352. |
| APA | Hu, Xi.,Feng, Ying.,Shen, Yu.,Zhao, Xiao-feng.,Yu, Juan-hong.,...&Leng, Ying.(2006).Antidiabetic effect of a novel non-thiazolidinedione PPAR gamma/alpha agonist on ob/ob mice.ACTA PHARMACOLOGICA SINICA,27(10),1346-1352. |
| MLA | Hu, Xi,et al."Antidiabetic effect of a novel non-thiazolidinedione PPAR gamma/alpha agonist on ob/ob mice".ACTA PHARMACOLOGICA SINICA 27.10(2006):1346-1352. |
入库方式： OAI收割
来源：上海药物研究所
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