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Differential response of Akt to cyclic AMP modulates drug sensitivity

文献类型：期刊论文

作者Zhao, Yunyu; Lou, Liguang
刊名BIOLOGICAL & PHARMACEUTICAL BULLETIN
出版日期2006-07
卷号29期号:7页码:1331-1334
关键词Akt cyclic AMP hepatocellular carcinoma proliferation drug sensitivity
ISSN号0918-6158
DOI10.1248/bpb.29.1331
文献子类Article
英文摘要Although Akt is known to be associated with drug resistance, its role in cyclic AMP (cAMP)-related inhibition of cell proliferation is not clear. Here, we report that Akt modulates the sensitivity of hepatocellular carcinoma cells to cAMP. Treatment of hepatocellular carcinoma cell lines (HepG(2) and Bel-7402) with cAMP inhibited proliferation, with HepG2 cells showing lower sensitivity to cAMP. Biochemical studies showed that cAMP increased FBS-stimulated Akt phosphorylation in HepG2 cells, but completely inhibited FBS-stimulated Akt phosphorylation in Bel-7402 cells, suggesting that the differential response of Akt to cAMP in these two cell lines might contribute to their differential sensitivity. LY294002, a phosphatidylinositol 3-kinase inhibitor that inhibits FBS-stimulated Akt phosphorylation, restored the sensitivity of HepG2 cells to cAMP and API-2 (Akt/protein kinase B signaling inhibitor-2) also showed similar effect. These results collectively indicate that the response level of Akt to cAMP may play a critical role in determining drug sensitivity.
WOS关键词CELL LUNG-CANCER ; RESISTANCE ; CHEMOTHERAPY ; INVOLVEMENT ; PATHWAY ; TAMOXIFEN ; RADIATION ; HEPATOMA ; CAMP
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000239542300006
出版者PHARMACEUTICAL SOC JAPAN
源URL[http://119.78.100.183/handle/2S10ELR8/273544]  
专题药理学第一研究室
通讯作者Lou, Liguang
作者单位Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Zhao, Yunyu,Lou, Liguang. Differential response of Akt to cyclic AMP modulates drug sensitivity[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2006,29(7):1331-1334.
APA Zhao, Yunyu,&Lou, Liguang.(2006).Differential response of Akt to cyclic AMP modulates drug sensitivity.BIOLOGICAL & PHARMACEUTICAL BULLETIN,29(7),1331-1334.
MLA Zhao, Yunyu,et al."Differential response of Akt to cyclic AMP modulates drug sensitivity".BIOLOGICAL & PHARMACEUTICAL BULLETIN 29.7(2006):1331-1334.

入库方式： OAI收割

来源：上海药物研究所

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