Altered regulation of Src upon cell detachment protects human lung adenocarcinoma cells from anoikis
文献类型：期刊论文
| 作者 | Wei, L; Yang, Y ; Zhang, X; Yu, Q
|
| 刊名 | ONCOGENE
 |
| 出版日期 | 2004-12-02 |
| 卷号 | 23期号:56页码:9052-9061 |
| 关键词 | Src anoikis lung cancer tyrosine phosphorylation |
| ISSN号 | 0950-9232 |
| DOI | 10.1038/sj.onc.1208091 |
| 文献子类 | Article |
| 英文摘要 | Src plays an important role in cell proliferation, differentiation, adhesion, and migration. Altered Src activity has been strongly implicated in the development, growth, progression, and metastasis of human cancers. We have analysed the change and regulation of Src upon cell detachment in anoikis-resistant human lung adenocarcinoma cells and compared with that of relatively normal and anoikis-sensitive epithelial cells. We found that Src activity was increased in the anoikis-resistant lung tumor cells when they were detached and cultured in suspension. The detachment-induced Src activation in the tumor cells compensates for the loss of cell survival signals caused by disruption of cell-matrix interactions and contributes to anoikis resistance of the tumor cells. Pyk2, rather than PI 3K/Akt or Erk, appears to be the key downstream effecter of Src in mediating the cell survival signals. The increased Src activity is mainly due to the phosphorylation of Tyr-419, rather than the dephosphorylation of Tyr-530 of Src protein. PDGFR, not FAK or EGFR, appears to be the upstream protein tyrosine kinase responsible for the detachment-induced Src activation in the lung tumor cells. The increased Src activity upon cell detachment may contribute to the metastasis potential of malignant tumors. |
| WOS关键词 | TYROSINE KINASE-ACTIVITY ; FOCAL ADHESION KINASE ; HUMAN-COLON CARCINOMA ; C-SRC ; EPITHELIAL-CELLS ; V-SRC ; PREMALIGNANT EPITHELIA ; PP60C-SRC ACTIVITY ; GENE-PRODUCT ; CANCER CELLS |
| 资助项目 | NIGMS NIH HHS[R01 GM59678] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:000225492800006 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273978]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Yu, Q |
| 作者单位 | 1.Boston Univ, Med Ctr, Dept Biochem, Boston, MA 02118 USA 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Boston Univ, Sch Med, Ctr Pulm, Dept Med, Boston, MA 02118 USA |
| 推荐引用方式 GB/T 7714 | Wei, L,Yang, Y,Zhang, X,et al. Altered regulation of Src upon cell detachment protects human lung adenocarcinoma cells from anoikis[J]. ONCOGENE,2004,23(56):9052-9061. |
| APA | Wei, L,Yang, Y,Zhang, X,&Yu, Q.(2004).Altered regulation of Src upon cell detachment protects human lung adenocarcinoma cells from anoikis.ONCOGENE,23(56),9052-9061. |
| MLA | Wei, L,et al."Altered regulation of Src upon cell detachment protects human lung adenocarcinoma cells from anoikis".ONCOGENE 23.56(2004):9052-9061. |
入库方式： OAI收割
来源：上海药物研究所
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