Acidic oligosaccharide sugar chain, a marine-derived acidic oligosaccharide, inhibits the cytotoxicity and aggregation of amyloid beta protein
文献类型：期刊论文
| 作者 | Hu, JF; Geng, MY ; Li, J; Xin, XL; Wang, J; Tang, MK; Zhang, JT; Zhang, X; Ding, J
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| 刊名 | JOURNAL OF PHARMACOLOGICAL SCIENCES
 |
| 出版日期 | 2004-06 |
| 卷号 | 95期号:2页码:248-255 |
| 关键词 | acidic oligosaccharide sugar chain amyloid beta protein neurotoxicity aggregation |
| ISSN号 | 1347-8613 |
| DOI | 10.1254/jphs.FPJ04004X |
| 文献子类 | Article |
| 英文摘要 | In this paper, we investigated interactions of the acidic oligosaccharide sugar chain (AOSC), derived from brown algae Echlonia kurome OKAM, with amyloid beta protein (Abeta). We observed that AOSC inhibited the toxicity induced by Abeta in both primarily cortical cells and the SH-SY5Y cell line. We also observed that AOSC inhibited the apoptosis induced by Abeta in SH-SY5Y by reducing the elevated level of intracellular calcium concentration ([Ca2+](i)) and suppressing the generation of reactive oxygen species. Surface plasmon resonance analysis demonstrated that AOSC had affinity for both freshly-dissolved Abeta and 48-h incubated Abeta. Furthermore, AOSC blocked the fibril formation of Abeta, which may be responsible for its anti-cytotoxic effects. Thus, our results indicate that AOSC might be a potentially therapeutic compound for Alzheimer's disease. |
| WOS关键词 | ALZHEIMERS-DISEASE ; A-BETA ; FIBRIL FORMATION ; OXIDATIVE STRESS ; HEPARIN-BINDING ; PC12 CELLS ; PEPTIDE ; GLYCOSAMINOGLYCANS ; GROWTH ; BRAIN |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000222275700016 |
| 出版者 | JAPANESE PHARMACOLOGICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274074]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Geng, MY |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Ocean Univ China, Dept Pharmacol, Marine Drug & Food Inst, Qingdao 266003, Peoples R China 3.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China 4.Peking Union Med Coll, Beijing 100050, Peoples R China 5.Huddinge Univ Hosp, Karolinska Inst, Div Mol Neuropharmacol, Dept Neurotec,Novum KFC, S-14186 Huddinge, Sweden |
| 推荐引用方式 GB/T 7714 | Hu, JF,Geng, MY,Li, J,et al. Acidic oligosaccharide sugar chain, a marine-derived acidic oligosaccharide, inhibits the cytotoxicity and aggregation of amyloid beta protein[J]. JOURNAL OF PHARMACOLOGICAL SCIENCES,2004,95(2):248-255. |
| APA | Hu, JF.,Geng, MY.,Li, J.,Xin, XL.,Wang, J.,...&Ding, J.(2004).Acidic oligosaccharide sugar chain, a marine-derived acidic oligosaccharide, inhibits the cytotoxicity and aggregation of amyloid beta protein.JOURNAL OF PHARMACOLOGICAL SCIENCES,95(2),248-255. |
| MLA | Hu, JF,et al."Acidic oligosaccharide sugar chain, a marine-derived acidic oligosaccharide, inhibits the cytotoxicity and aggregation of amyloid beta protein".JOURNAL OF PHARMACOLOGICAL SCIENCES 95.2(2004):248-255. |
入库方式： OAI收割
来源：上海药物研究所
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