Salvianolate inhibits proliferation and endothelin release in cultured rat mesangial cells
文献类型：期刊论文
| 作者 | Xu, M; Wang, YP ; Luo, WB; Xuan, LJ
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2001-07 |
| 卷号 | 22期号:7页码:629-633 |
| 关键词 | salvianolate glomerular mesangium cell division endothelins cytotoxicity |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To study the effects of salvianolate, an aqueous extract of Radix Salviae Miltiorrhizae, on the proliferation and endothelin release of cultured rat mesangial cells. METHODS: The proliferation of mesangial cells was determined in terms of [H-3]thymidine uptake. The concentration of endothelin was measured by radioimmunoassay. The cytotoxicity of salvianolate was tested by tetrazolium (MTT) and lactic dehydrogenase (LDH) assay. RESULTS: Lipopolysaccharide (LPS) 10 mg/L increased the proliferation and endothelin release in cultured mesangial cells. When mesangial cells pretreated with 3, 10, and 30 mg/L of salvianolate were incubated for 4 h with LPS, salvianolate exhibited a concentration dependent inhibitory effect on proliferation and endothelin levels in the mesangial cells induced by LPS. Further more, the increased basal levels of mesangial cells proliferation and the endothelin release were also effectively inhibited by salvianolate 30 mg/L at 4, 8, and 12 h. Besides, no cytotoxicity of salvianolate was observed. CONCLUSION: These results indicate that salvianolate can inhibit mesangial cells proliferation, which may be related to the decrease of endothelin release. |
| WOS关键词 | MAGNESIUM LITHOSPERMATE-B ; PHOSPHOLIPASE-C ; EXPRESSION ; GLOMERULI ; RECEPTOR ; DISEASE ; FOS |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000169950000009 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274472]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Wang, YP |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Materia Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, M,Wang, YP,Luo, WB,et al. Salvianolate inhibits proliferation and endothelin release in cultured rat mesangial cells[J]. ACTA PHARMACOLOGICA SINICA,2001,22(7):629-633. |
| APA | Xu, M,Wang, YP,Luo, WB,&Xuan, LJ.(2001).Salvianolate inhibits proliferation and endothelin release in cultured rat mesangial cells.ACTA PHARMACOLOGICA SINICA,22(7),629-633. |
| MLA | Xu, M,et al."Salvianolate inhibits proliferation and endothelin release in cultured rat mesangial cells".ACTA PHARMACOLOGICA SINICA 22.7(2001):629-633. |
入库方式： OAI收割
来源：上海药物研究所
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