Quantitative comparison of ohmefentanyl isomers induced conditioning place preference in mice
文献类型：期刊论文
| 作者 | Guo, GW; Liu, ZH; Jin, WQ; Zhang, HP; Chen, XJ; Zhu, YC; Chi, ZQ
|
| 刊名 | LIFE SCIENCES
 |
| 出版日期 | 2001-04-13 |
| 卷号 | 68期号:21页码:2383-2390 |
| 关键词 | ohmefentanyl stereoisomers conditioned place preference addictive potential morphine |
| ISSN号 | 0024-3205 |
| DOI | 10.1016/S0024-3205(01)01030-X |
| 文献子类 | Article |
| 英文摘要 | Differences of analgesia and withdrawal response among ohmefentanyl stereoisomers have been studied. In the present study, Quantitative comparison of reinforcing effects of ohmefentanyl stereoisomers and morphine was performed by using a conditioned place preference design in mice. Results showed that morphine and ohmefentanyl stereoisomers were able to increase significantly the time spent in the drug-paired side with respect to vehicle treated animals. A good linear correlation between doses of drugs and number of mice with place preference was found within a given dose range. On the basis of the dose-response curve analysis, ohmefentanyl stereoisomers displayed a significant difference in place preference ED50. The addictive index (analgesic ED50 / place preference ED50) was used to assess the addictive potential of drugs. It was demonstrated that the addictive potential of ohmefentanyl stereoisomers did not exhibit a large difference as addictive index. Among these stereoisomers, the addictive potential of compound F9208 was markedly lower than that of morphine. (C) 2001 Elsevier Science Inc. All rights reserved. |
| WOS关键词 | MORPHINE-INDUCED ANALGESIA ; STEREOISOMERS ; COCAINE ; REWARD |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000168214600005 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274501]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Jin, WQ |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Meteria Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, GW,Liu, ZH,Jin, WQ,et al. Quantitative comparison of ohmefentanyl isomers induced conditioning place preference in mice[J]. LIFE SCIENCES,2001,68(21):2383-2390. |
| APA | Guo, GW.,Liu, ZH.,Jin, WQ.,Zhang, HP.,Chen, XJ.,...&Chi, ZQ.(2001).Quantitative comparison of ohmefentanyl isomers induced conditioning place preference in mice.LIFE SCIENCES,68(21),2383-2390. |
| MLA | Guo, GW,et al."Quantitative comparison of ohmefentanyl isomers induced conditioning place preference in mice".LIFE SCIENCES 68.21(2001):2383-2390. |
入库方式： OAI收割
来源：上海药物研究所
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