Induction of apoptosis in human leukemia K-562 and gastric carcinoma SGC-7901 cells by salvicine, a novel anticancer compound
文献类型：期刊论文
| 作者 | Qing, C; Jiang, C; Zhang, JS; Ding, J
|
| 刊名 | ANTI-CANCER DRUGS
 |
| 出版日期 | 2001-01 |
| 卷号 | 12期号:1页码:51-56 |
| 关键词 | apoptosis K-562 cell salvicine SGC-7901 cell |
| ISSN号 | 0959-4973 |
| DOI | 10.1097/00001813-200101000-00007 |
| 文献子类 | Article |
| 英文摘要 | Salvicine (a novel diterpenoid quinone compound) exhibited a marked antitumor activity on human solid tumor cell lines and BALB/c-nu human carcinoma xenografts in our earlier studies, and it has been chosen as a candidate anticarcinogenic compound in the preclinical research stage. The present study was undertaken in order to observe whether or not the antitumor effect of salvicine is associated with its ability to induce apoptosis. Our results show that salvicine is capable of inhibiting cell proliferation and Inducing characteristic changes of apoptosis in both human leukemia K-562 and gastric carcinoma SGC-7901 cells. These effects are dose and time dependent. The results of this study strongly suggest that the antitumor effect of salvicine is associated with its ability to induce apoptosis, Meanwhile, this study also shows that the activity of salvicine against K-562 and SGC-7901 cells is similar with regards to both growth inhibition and apoptosis induction, further indicating that salvicine causes these particular effects on solid tumor cells, [(C) 2001 Lippincott Williams & Wilkins.]. |
| WOS关键词 | ASSAY |
| WOS研究方向 | Oncology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000166756100007 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274533]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Ding, J |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qing, C,Jiang, C,Zhang, JS,et al. Induction of apoptosis in human leukemia K-562 and gastric carcinoma SGC-7901 cells by salvicine, a novel anticancer compound[J]. ANTI-CANCER DRUGS,2001,12(1):51-56. |
| APA | Qing, C,Jiang, C,Zhang, JS,&Ding, J.(2001).Induction of apoptosis in human leukemia K-562 and gastric carcinoma SGC-7901 cells by salvicine, a novel anticancer compound.ANTI-CANCER DRUGS,12(1),51-56. |
| MLA | Qing, C,et al."Induction of apoptosis in human leukemia K-562 and gastric carcinoma SGC-7901 cells by salvicine, a novel anticancer compound".ANTI-CANCER DRUGS 12.1(2001):51-56. |
入库方式： OAI收割
来源：上海药物研究所
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