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Comparison of physical dependence of ohmefentanyl stereoisomers in mice

文献类型：期刊论文

作者Guo, GW; He, Y; Jin, WQ; Zou, Y; Zhu, YC; Chi, ZQ
刊名LIFE SCIENCES
出版日期2000-06-02
卷号67期号:2页码:113-120
关键词ohmefentanyl stereoisomer morphine withdrawal physical dependence
ISSN号0024-3205
DOI10.1016/S0024-3205(00)00617-2
文献子类Article
英文摘要Stereo-structural difference of ohmefentanyl stereoisomers on analgesic action and receptor affinity has been studied. To assess the difference of ohmefentanyl stereoisomers in physical dependence, the potency of physical dependence was quantified by estimating the ED50 value of ohmefentanyl stereoisomers in the naloxone-precipitated jumping test in mice. Morphine was used to assess the method and as a drug of comparison. The results indicate that the degree of physical dependence of morphine can been quantified by estimating the ED50 value of morphine withdrawal jumping induced by naloxone. A significant difference was observed in withdrawal jumping ED50 values among ohmefentanyl stereoisomers. Of these isomers, F9202 and F9204 had similarly potent analgesic action, but very significant difference in naloxone precipitated withdrawal response. Dependent potency index of F9204 was 618-fold weaker than that of F9202. It is concluded that a stereo-structural difference in physical dependence is found to exist among ohmefentanyl stereoisomers. Compound F9204 displayed a strong analgesic action and weak physical dependent potency. (C) 2000 Elsevier Science Inc. All rights reserved.
WOS关键词OPIOID RECEPTORS ; MORPHINE-TOLERANCE ; BINDING ; TOLERANCE/DEPENDENCE ; DIHYDROETORPHINE ; ENANTIOMERS ; SELECTIVITY ; POTENCY ; BRAIN ; RAT
WOS研究方向Research & Experimental Medicine ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000087547300002
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/274610]  
专题药理学第一研究室
通讯作者Jin, WQ
作者单位Chinese Acad Sci, Shanghai Inst Meteria Med, Dept Pharmacol 2, Shanghai 200031, Peoples R China
推荐引用方式
GB/T 7714		 Guo, GW,He, Y,Jin, WQ,et al. Comparison of physical dependence of ohmefentanyl stereoisomers in mice[J]. LIFE SCIENCES,2000,67(2):113-120.
APA Guo, GW,He, Y,Jin, WQ,Zou, Y,Zhu, YC,&Chi, ZQ.(2000).Comparison of physical dependence of ohmefentanyl stereoisomers in mice.LIFE SCIENCES,67(2),113-120.
MLA Guo, GW,et al."Comparison of physical dependence of ohmefentanyl stereoisomers in mice".LIFE SCIENCES 67.2(2000):113-120.

入库方式： OAI收割

来源：上海药物研究所

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