Effects of anordrin, droloxifene, nomegestrol, and mifepristone on cultured rat luteal cell apoptosis
文献类型：期刊论文
| 作者 | Leng, Y ; Yang, B; Cao, L; Gu, ZP
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1999-05 |
| 卷号 | 20期号:5页码:400-404 |
| 关键词 | corpus luteum cultured cells apoptosis necrosis flow cytometry DNA anordrin droloxifene nomegestrol mifepristone |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To study the effect of four kinds of antifertility agents anordrin(Ano), droloxifene(Dro), nomegestrol (Nom), and mifepristone (Mif) on luteal cell apoptosis. METHODS: Cultured rat luteal cells were incubated with different agents. HE stain was used to observe morphological changes. Extracted DNA was electrophoresed on agarose gel. Apoptotic cells were quantitated by flow cytometry. RESULTS: All 4 drugs reduced cell viability. Dro induced apoptosis while the other 3 drugs induced necrosis. Typical DNA ladders were observed after cells were incubated with Dro and there were 15.4%, 75.4%, or 90.5% apoptotic cells after treatment with Dro 1.25, 2.5, or 3.15 mg.L-1, respectively. CONCLUSION: Dro induced apoptosis while Ano, Nom, and Mif induced necrosis in cultured rat luteal cells. |
| WOS关键词 | LUTEOLYSIS ; RECEPTOR |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000080221600004 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274728]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Gu, ZP |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Leng, Y,Yang, B,Cao, L,et al. Effects of anordrin, droloxifene, nomegestrol, and mifepristone on cultured rat luteal cell apoptosis[J]. ACTA PHARMACOLOGICA SINICA,1999,20(5):400-404. |
| APA | Leng, Y,Yang, B,Cao, L,&Gu, ZP.(1999).Effects of anordrin, droloxifene, nomegestrol, and mifepristone on cultured rat luteal cell apoptosis.ACTA PHARMACOLOGICA SINICA,20(5),400-404. |
| MLA | Leng, Y,et al."Effects of anordrin, droloxifene, nomegestrol, and mifepristone on cultured rat luteal cell apoptosis".ACTA PHARMACOLOGICA SINICA 20.5(1999):400-404. |
入库方式： OAI收割
来源：上海药物研究所
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