中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Effects of anordrin, droloxifene, nomegestrol, and mifepristone on cultured rat luteal cell apoptosis

文献类型:期刊论文

作者Leng, Y; Yang, B; Cao, L; Gu, ZP
刊名ACTA PHARMACOLOGICA SINICA
出版日期1999-05
卷号20期号:5页码:400-404
关键词corpus luteum cultured cells apoptosis necrosis flow cytometry DNA anordrin droloxifene nomegestrol mifepristone
ISSN号0253-9756
文献子类Article
英文摘要AIM: To study the effect of four kinds of antifertility agents anordrin(Ano), droloxifene(Dro), nomegestrol (Nom), and mifepristone (Mif) on luteal cell apoptosis. METHODS: Cultured rat luteal cells were incubated with different agents. HE stain was used to observe morphological changes. Extracted DNA was electrophoresed on agarose gel. Apoptotic cells were quantitated by flow cytometry. RESULTS: All 4 drugs reduced cell viability. Dro induced apoptosis while the other 3 drugs induced necrosis. Typical DNA ladders were observed after cells were incubated with Dro and there were 15.4%, 75.4%, or 90.5% apoptotic cells after treatment with Dro 1.25, 2.5, or 3.15 mg.L-1, respectively. CONCLUSION: Dro induced apoptosis while Ano, Nom, and Mif induced necrosis in cultured rat luteal cells.
WOS关键词LUTEOLYSIS ; RECEPTOR
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000080221600004
出版者ACTA PHARMACOLOGICA SINICA
源URL[http://119.78.100.183/handle/2S10ELR8/274728]  
专题药理学第一研究室
通讯作者Gu, ZP
作者单位Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China
推荐引用方式
GB/T 7714
Leng, Y,Yang, B,Cao, L,et al. Effects of anordrin, droloxifene, nomegestrol, and mifepristone on cultured rat luteal cell apoptosis[J]. ACTA PHARMACOLOGICA SINICA,1999,20(5):400-404.
APA Leng, Y,Yang, B,Cao, L,&Gu, ZP.(1999).Effects of anordrin, droloxifene, nomegestrol, and mifepristone on cultured rat luteal cell apoptosis.ACTA PHARMACOLOGICA SINICA,20(5),400-404.
MLA Leng, Y,et al."Effects of anordrin, droloxifene, nomegestrol, and mifepristone on cultured rat luteal cell apoptosis".ACTA PHARMACOLOGICA SINICA 20.5(1999):400-404.

入库方式: OAI收割

来源:上海药物研究所

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