Effect of (-)-stepholidine on serum prolactin level of female rats
文献类型：期刊论文
| 作者 | Zou, LL; Chen, Y ; Song, YY; Jin, GZ
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1996-07 |
| 卷号 | 17期号:4页码:311-314 |
| 关键词 | (-)-stepholidine prolactin radioimmunoassay dopamine antagonists pergolide |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To study the effect of (-)-stepholidine (SPD) on serum prolactin (PRL) level and elucidate its pharmacological action on,dopamine D-2 receptors. METHOD: After ip administration of dopamine receptor agonist, antagonist, or SPD, the serum PRL levels were determined by radioimmunoassay. RESULTS: SPD (24 mg . kg(-1), ip) caused a rapid rise in serum PRL level, lasting more than 1 h. SPD 0.2-40 mg . kg(-1) raised serum PRL level in a dose-dependent manner with ED(50) of 3.7 mg . kg(-1) (95 % confidence limits, 2.6-4.3 mg . kg(-1)) and PRL maximal level of 448 +/-64 mu g . L(-1). Pergolide 2 mg . kg(-1) ip caused a decrease (P < 0.01 vs saline) of PRL level, which was partially attenuated by SPD of 5 mg . kg(-1) and completely abolished by 10 mg . kg(-1). CONCLUSION: SPD is a dopamine D-2 receptor antagonist. |
| WOS关键词 | L-STEPHOLIDINE ; DOPAMINE ; TETRAHYDROPROTOBERBERINES ; RECEPTORS ; BRAIN |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:339761 |
| WOS记录号 | WOS:A1996UW39400007 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274967]  |
| 专题 | 药理学第一研究室 院士及顾问专家 国家新药筛选中心 |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | Zou, LL,Chen, Y,Song, YY,et al. Effect of (-)-stepholidine on serum prolactin level of female rats[J]. ACTA PHARMACOLOGICA SINICA,1996,17(4):311-314. |
| APA | Zou, LL,Chen, Y,Song, YY,&Jin, GZ.(1996).Effect of (-)-stepholidine on serum prolactin level of female rats.ACTA PHARMACOLOGICA SINICA,17(4),311-314. |
| MLA | Zou, LL,et al."Effect of (-)-stepholidine on serum prolactin level of female rats".ACTA PHARMACOLOGICA SINICA 17.4(1996):311-314. |
入库方式： OAI收割
来源：上海药物研究所
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