Unusual Cytotoxic Steroidal Saponins from the Gorgonian Astrogorgia dumbea
文献类型：期刊论文
| 作者 | Lu, Ya-Nan2; Cui, Ping3; Tian, Xiao-Qing2; Lou, Li-Guang1 ; Fan, Cheng-Qi2
|
| 刊名 | PLANTA MEDICA
 |
| 出版日期 | 2016-06 |
| 卷号 | 82期号:9-10页码:882-887 |
| 关键词 | Astrogorgia dumbea Plexauridae steroidal saponin astrogorgiosides A-C cytotoxic activity |
| ISSN号 | 0032-0943 |
| DOI | 10.1055/s-0042-106168 |
| 文献子类 | Article |
| 英文摘要 | Three steroidal saponins, including astrogorgiosides A (1) and B (2) bearing acetamido-glucose moieties, and astrogorgioside C (3) with a 19-nor and bearing an aromatized B ring steroid aglycone, together with a known major saponin dimorphoside A (4), were obtained from the gorgonian Astrogorgia dumbea collected near Dongshan Island in East China Sea. Structures of these compounds were elucidated by in-depth spectral and chemical methods, including 2D-NMR, HR-ESI-ESI-MS spectra, and acidic hydrolysis. For the first time, acetamido-glucose moiety is being reported from a gorgonian. The B-ring aromatized steroid aglycone of compound 3 is also rare in marine natural products. Compounds 1-3 exhibited moderate cytotoxic activity with IC50 values of 26.8-45.6 mu M against human tumor cells Bel-7402 and K562. |
| WOS关键词 | BIOACTIVE MARINE METABOLITES ; INHIBITORS ; GLYCOSIDES |
| 资助项目 | Natural Science Foundation of Shanghai[11ZR1449800] ; foundation of Key Laboratory of Marine Bio-resources Sustainable Utilization[LMB101003] ; special research fund for the national non-profit institutes (East China Sea Fisheries Research Institute), of P.R. China[2007M18] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000378913600014 |
| 出版者 | GEORG THIEME VERLAG KG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276016]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Fan, Cheng-Qi |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Medica, Shanghai, Peoples R China 2.Chinese Acad Fishery Sci, Key Lab East China Sea & Ocean Fishery Resources, Minist Agr, East China Sea Fisheries Res Inst, Shanghai, Peoples R China; 3.Changchun Univ Chinese Med, Changchun, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Lu, Ya-Nan,Cui, Ping,Tian, Xiao-Qing,et al. Unusual Cytotoxic Steroidal Saponins from the Gorgonian Astrogorgia dumbea[J]. PLANTA MEDICA,2016,82(9-10):882-887. |
| APA | Lu, Ya-Nan,Cui, Ping,Tian, Xiao-Qing,Lou, Li-Guang,&Fan, Cheng-Qi.(2016).Unusual Cytotoxic Steroidal Saponins from the Gorgonian Astrogorgia dumbea.PLANTA MEDICA,82(9-10),882-887. |
| MLA | Lu, Ya-Nan,et al."Unusual Cytotoxic Steroidal Saponins from the Gorgonian Astrogorgia dumbea".PLANTA MEDICA 82.9-10(2016):882-887. |
入库方式： OAI收割
来源：上海药物研究所
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