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Discovery and structure activity relationship study of novel indazole amide inhibitors for extracellular signal-regulated kinase1/2 (ERK1/2)

文献类型：期刊论文

作者Li, Lei1; Liu, Feifei2; Jin, Nan2; Tang, Shuai2; Chen, Zhuxi1,2; Yang, Xiaotong2; Ding, Jian2; Geng, Meiyu2; Jiang, Lei1; Huang, Min2
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
出版日期2016-06-01
卷号26期号:11页码:2600-2604
关键词ERK1/2 kinase inhibitor Indazole amide Structure based drug design
ISSN号0960-894X
DOI10.1016/j.bmcl.2016.04.029
文献子类Article
英文摘要The discovery and optimization of a series of indazole amide based extracellular signal-regulated kinase inhibitors via structure/knowledge based drug design and kinase screen is reported. The optimized compounds demonstrate potent inhibition of ERK1/2 enzyme activity, growth of BRAF mutant HT29 cells and ERK signaling in HT29 cells. (C) 2016 Elsevier Ltd. All rights reserved.
WOS关键词MAP KINASE ; ERK2 KINASE ; CANCER ; BRAF
WOS研究方向Pharmacology & Pharmacy ; Chemistry
语种英语
WOS记录号WOS:000374988600007
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/276031]  
专题药理学第一研究室
通讯作者Huang, Min; Cao, Jianhua
作者单位1.Green Valley Pharmaceut Co Ltd, Green Valley Res Inst, 421 Niudun Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, 555 Zuchongzhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Li, Lei,Liu, Feifei,Jin, Nan,et al. Discovery and structure activity relationship study of novel indazole amide inhibitors for extracellular signal-regulated kinase1/2 (ERK1/2)[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016,26(11):2600-2604.
APA Li, Lei.,Liu, Feifei.,Jin, Nan.,Tang, Shuai.,Chen, Zhuxi.,...&Cao, Jianhua.(2016).Discovery and structure activity relationship study of novel indazole amide inhibitors for extracellular signal-regulated kinase1/2 (ERK1/2).BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,26(11),2600-2604.
MLA Li, Lei,et al."Discovery and structure activity relationship study of novel indazole amide inhibitors for extracellular signal-regulated kinase1/2 (ERK1/2)".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 26.11(2016):2600-2604.

入库方式： OAI收割

来源：上海药物研究所

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