Recent developments in antivirals against hepatitis B virus
文献类型：期刊论文
| 作者 | Wang, Ya-Juan; Yang, Li; Zuo, Jian-Ping
|
| 刊名 | VIRUS RESEARCH
 |
| 出版日期 | 2016-02-02 |
| 卷号 | 213页码:205-213 |
| 关键词 | Hepatitis B Antiviral therapy Inhibitory drugs Host immune regulators |
| ISSN号 | 0168-1702 |
| DOI | 10.1016/j.virusres.2015.12.014 |
| 文献子类 | Review |
| 英文摘要 | Chronic hepatitis B virus (HBV) infection (CHB) is a major cause of cirrhosis and hepatocellular carcinoma (HCC). Although the availability of HBV vaccines effectively reduces the incidence of HBV infection, the healthcare burden from CHB remains high. Several antiviral agents, such as (pegylated-) interferon-alpha and nucleos(t)ide analogs are approved by US FDA for chronic HBV infection management. Entecavir (ETV) and tenofovir disoproxil fumarate (TDF) have been recommended as the first-line anti-HBV drugs for excellent viral suppression with a low risk of antiviral resistance, but the cost and need for essentially life-long treatment are considerable challenges. And none of these current treatments can eradicate the intracellular virus. Given these issues, there is still an unmet medical need for an efficient HBV cure. We summarize here the key developments of antivirals against hepatitis B virus, including HBV replication cycle inhibitors and host immune regulators. (C) 2015 Elsevier B.V. All rights reserved. |
| WOS关键词 | COTRANSPORTING POLYPEPTIDE NTCP ; IMMUNOSUPPRESSIVE DRUG-THERAPY ; LARGE ENVELOPE PROTEIN ; IN-VIVO ; LIFE-CYCLE ; RECEPTOR RECOGNITION ; MEMBRANE TRANSPORTER ; EFFECTOR NUCLEASES ; CLINICAL-PRACTICE ; HBV REPLICATION |
| WOS研究方向 | Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000371840600023 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276153]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Yang, Li; Zuo, Jian-Ping |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Zuchongzhi Rd 555, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Ya-Juan,Yang, Li,Zuo, Jian-Ping. Recent developments in antivirals against hepatitis B virus[J]. VIRUS RESEARCH,2016,213:205-213. |
| APA | Wang, Ya-Juan,Yang, Li,&Zuo, Jian-Ping.(2016).Recent developments in antivirals against hepatitis B virus.VIRUS RESEARCH,213,205-213. |
| MLA | Wang, Ya-Juan,et al."Recent developments in antivirals against hepatitis B virus".VIRUS RESEARCH 213(2016):205-213. |
入库方式： OAI收割
来源：上海药物研究所
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