Intra-tumor heterogeneity of cancer cells and its implications for cancer treatment
文献类型：期刊论文
| 作者 | Sun, Xiao-xiao; Yu, Qiang
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2015-10 |
| 卷号 | 36期号:10页码:1219-1227 |
| 关键词 | cancer cells intra-tumor heterogeneity genetic heterogeneity signal transduction cancer therapy |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2015.92 |
| 文献子类 | Review |
| 英文摘要 | Recent studies have revealed extensive genetic and non-genetic variation across different geographical regions of a tumor or throughout different stages of tumor progression, which is referred to as intra-tumor heterogeneity. Several causes contribute to this phenomenon, including genomic instability, epigenetic alteration, plastic gene expression, signal transduction, and microenvironmental differences. These variables may affect key signaling pathways that regulate cancer cell growth, drive phenotypic diversity, and pose challenges to cancer treatment. Understanding the mechanisms underlying this heterogeneity will support the development of effective therapeutic strategies. |
| WOS关键词 | ACUTE MYELOID-LEUKEMIA ; STOCHASTIC GENE-EXPRESSION ; SINGLE-CELL ; STEM-CELLS ; LUNG-CANCER ; INTRATUMORAL HETEROGENEITY ; SOLID TUMORS ; HUMAN-COLON ; HEMATOPOIETIC-CELL ; INITIATING CELLS |
| 资助项目 | China Ministry of Science and Technology Key New Drug Creation and Manufacturing Program[2013ZX09102015] ; China Ministry of Science and Technology Key New Drug Creation and Manufacturing Program[2014ZX09102001002] ; China Ministry of Science and Technology Research[2013ZX10002010-009] ; National Natural Science Foundation of China[81302792] ; National Natural Science Foundation of China[81373447] ; National Natural Science Foundation of China[91413121] ; National Natural Science Foundation of China[91213304] ; China National Key Basic Research Program[2012CB910704] ; China National Key Basic Research Program[2013CB910900] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5531931 |
| WOS记录号 | WOS:000362459200008 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276385]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Yu, Qiang |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Xiao-xiao,Yu, Qiang. Intra-tumor heterogeneity of cancer cells and its implications for cancer treatment[J]. ACTA PHARMACOLOGICA SINICA,2015,36(10):1219-1227. |
| APA | Sun, Xiao-xiao,&Yu, Qiang.(2015).Intra-tumor heterogeneity of cancer cells and its implications for cancer treatment.ACTA PHARMACOLOGICA SINICA,36(10),1219-1227. |
| MLA | Sun, Xiao-xiao,et al."Intra-tumor heterogeneity of cancer cells and its implications for cancer treatment".ACTA PHARMACOLOGICA SINICA 36.10(2015):1219-1227. |
入库方式： OAI收割
来源：上海药物研究所
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