Synthesis and anticancer activity of a new water-soluble derivative of heptaplatin, cis-{Pt(II)[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane](3-acetoxyl-cyclobutane-1,1-dicarboxylato)}
文献类型：期刊论文
| 作者 | Jiang, Jing2; Lei, Jing1; Chen, Xi-Zhu2; Lou, Li-Guang3 ; Ye, Qing-Song2; Chang, Qiao-Wen2; Xu, Yong-Ping3; Liu, Wei-Ping2
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| 刊名 | RESEARCH ON CHEMICAL INTERMEDIATES
 |
| 出版日期 | 2015-09 |
| 卷号 | 41期号:9页码:6149-6155 |
| 关键词 | Platinum complexes Heptaplatin Synthesis Anticancer |
| ISSN号 | 0922-6168 |
| DOI | 10.1007/s11164-014-1728-0 |
| 文献子类 | Article |
| 英文摘要 | A new water-soluble derivative of heptaplatin, cis-{Pt(II)[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane](3-acetoxyl-cyclobutane-1,1-dicarboxylato)} has been synthesized, characterized by elemental analysis, MS, IR, and H-1, C-13 NMR, and evaluated for in vitro anticancer activity in four human cancer cell lines. The stability of the derivative in water was also investigated by monitoring the changes of H-1 NMR in D2O. The results reveal that the new derivative has good solubility and stability in water and also shows high anticancer activity against gastric cancer cells, ovarian cancer cells, and colon cancer cells. Therefore, it is worthy of further evaluation for in vivo antitumor activity and toxicity. |
| WOS关键词 | PLATINUM COMPLEXES ; ANTITUMOR-ACTIVITY ; DESIGN ; ANALOG ; DRUGS |
| 资助项目 | National Science Foundation of P. R. China[21161010] ; China National Research and Development Program[2012BAE06B08] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000361140200017 |
| 出版者 | SPRINGER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276414]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Liu, Wei-Ping |
| 作者单位 | 1.Hunan Normal Univ, Sch Chem, Changsha 410081, Hunan, Peoples R China; 2.Kunming Inst Precious Met, State Key Lab Adv Technol PGM, Kunming 50106, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Jing,Lei, Jing,Chen, Xi-Zhu,et al. Synthesis and anticancer activity of a new water-soluble derivative of heptaplatin, cis-{Pt(II)[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane](3-acetoxyl-cyclobutane-1,1-dicarboxylato)}[J]. RESEARCH ON CHEMICAL INTERMEDIATES,2015,41(9):6149-6155. |
| APA | Jiang, Jing.,Lei, Jing.,Chen, Xi-Zhu.,Lou, Li-Guang.,Ye, Qing-Song.,...&Liu, Wei-Ping.(2015).Synthesis and anticancer activity of a new water-soluble derivative of heptaplatin, cis-{Pt(II)[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane](3-acetoxyl-cyclobutane-1,1-dicarboxylato)}.RESEARCH ON CHEMICAL INTERMEDIATES,41(9),6149-6155. |
| MLA | Jiang, Jing,et al."Synthesis and anticancer activity of a new water-soluble derivative of heptaplatin, cis-{Pt(II)[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane](3-acetoxyl-cyclobutane-1,1-dicarboxylato)}".RESEARCH ON CHEMICAL INTERMEDIATES 41.9(2015):6149-6155. |
入库方式： OAI收割
来源：上海药物研究所
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