Inhibitory activities of Lignum Sappan extractives on growth and growth-related signaling of tumor cells
文献类型：期刊论文
| 作者 | Zhang Qing ; Liu Jing-Li; Qi Xiao-Man; Qi Chun-Ting; Yu Qiang
|
| 刊名 | CHINESE JOURNAL OF NATURAL MEDICINES
 |
| 出版日期 | 2014-08 |
| 卷号 | 12期号:8页码:607-612 |
| 关键词 | Caesalpinia sappan L. Lignum Sappan Anti-tumor activity Cell cycle blocker Signaling pathway inhibitor Synergy |
| ISSN号 | 2095-6975 |
| DOI | 10.3724/SP.J.1009.2014.00607 |
| 文献子类 | Article |
| 英文摘要 | AIM: To investigate the active constituents of Lignum Sappan (Caesalpinia sappan L.) on growth-related signaling and cell mitosis. METHOD: The influence of the ethyl acetate (EtOAc) extract of Lignum Sappan and its constituents on growth-related signaling were evaluated by a luciferase assay in cells stably- transfected with NF-kappa B, STAT1, or STAT3 responsive luciferase reporter plasmid. The inhibitory effect on the cell cycle was determined by flow cytometric analysis. The anti-tumor activities were assessed in vitro and in vivo. RESULTS: The EtOAc extract of Lignum Sappan had inhibitory activities on growth-related signaling and cell mitosis. Three major active compounds were sappanchalcone, brazilin, and butein. Sappanchalcone blocked cell cycle progression in the G(2)/M phase, brazilin inhibited TNF alpha/NF-kappa B signaling, while butein inhibited IL-6/STAT3 signaling, as well as TNF alpha/NF-kappa B signaling. The three compounds all demonstrated cytotoxic activities against human tumor cells in vitro. In a S180 tumor cell-bearing mice model, the anti-tumor efficacy of the EtOAc extract was better than the individual compounds acting alone. CONCLUSION: These results indicate that Lignum Sappan contains multiple active compounds with different antitumor activities, which act synergistically to enhance their anti-tumor effects. The EtOAc extract of Lignum Sappan may be better than individual active constituent as a novel medicine for the treatment of cancer. |
| WOS关键词 | NF-KAPPA-B ; CAESALPINIA-SAPPAN ; IN-VITRO ; OXIDATIVE STRESS ; CANCER CELLS ; CONSTITUENTS ; INFLAMMATION ; THERAPY ; HEARTWOOD ; PATHWAYS |
| 资助项目 | China National Natural Science Foundation Grant[91129701] ; China National Natural Science Foundation Grant[81102848] ; China National Natural Science Foundation Grant[31129004] ; China National Science and Technology 973 grant[2012CB910704] |
| WOS研究方向 | Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5219162 |
| WOS记录号 | WOS:000342108100007 |
| 出版者 | CHINESE JOURNAL NATURAL MEDICINES |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276951]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Yu Qiang |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang Qing,Liu Jing-Li,Qi Xiao-Man,et al. Inhibitory activities of Lignum Sappan extractives on growth and growth-related signaling of tumor cells[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2014,12(8):607-612. |
| APA | Zhang Qing,Liu Jing-Li,Qi Xiao-Man,Qi Chun-Ting,&Yu Qiang.(2014).Inhibitory activities of Lignum Sappan extractives on growth and growth-related signaling of tumor cells.CHINESE JOURNAL OF NATURAL MEDICINES,12(8),607-612. |
| MLA | Zhang Qing,et al."Inhibitory activities of Lignum Sappan extractives on growth and growth-related signaling of tumor cells".CHINESE JOURNAL OF NATURAL MEDICINES 12.8(2014):607-612. |
入库方式： OAI收割
来源：上海药物研究所
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