Angoline: A selective IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum
文献类型：期刊论文
| 作者 | Liu, Jiawei1; Zhang, Qing2 ; Ye, Yushan1; Li, Wuguo1; Qiu, Junxin1; Liu, Jingli2; Zhan, Ruoting1; Chen, Weiwen1; Yu, Qiang2
|
| 刊名 | PHYTOMEDICINE
 |
| 出版日期 | 2014-07 |
| 卷号 | 21期号:8-9页码:1088-1091 |
| 关键词 | STAT3 signaling pathway Inhibitor Zanthoxylum nitidum Angoline |
| ISSN号 | 0944-7113 |
| DOI | 10.1016/j.phymed.2014.04.001 |
| 文献子类 | Article |
| 英文摘要 | STAT3 signaling pathway is an important target for human cancer therapy. Thus, the identification of small-molecules that target STAT3 signaling will be of great interests in the development of anticancer agents. The aim of this study was to identify novel inhibitors of STAT3 pathway from the roots of Zanthoxylum nitidum (Roxb.) DC. The bioassay-guided fractionation of MeOH extract of Z. nitidum using a STAT3-responsive gene reporter assay led to the isolation of angoline (1) as a potent and selective inhibitor of the STAT3 signaling pathway (IC50 = 11.56 mu M). Angoline inhibited STAT3 phosphorylation and its target gene expression and consequently induced growth inhibition of human cancer cells with constitutively activated STAT3 (IC50 = 3.14-4.72 mu M). This work provided a novel lead for the development of anti-cancer agents targeting the STAT3 signaling pathway. (C) 2014 Elsevier GmbH. All rights reserved. |
| WOS关键词 | BENZOPHENANTHRIDINE ALKALOIDS ; CONSTITUTIVE ACTIVATION ; CARCINOMA CELLS ; STAT3 ; APOPTOSIS |
| 资助项目 | China National Natural Science Foundation[81373432] ; Special Project on the Integration of Industry, Education and Research of Guangdong Province[2009B090300202] ; Guangzhuo Science and Technology Program Grant[132000207] ; 211 Project Grant of Guangzhou University of Chinese Medicine[2009319] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000337932000011 |
| 出版者 | ELSEVIER GMBH, URBAN & FISCHER VERLAG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277013]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Liu, Jingli |
| 作者单位 | 1.Guangzhou Univ Chinese Med, Res Ctr Med Plants Resource Sci & Engn, Minist Educ, Key Lab Chinese Med Plants Resource Lingnan, Guangzhou 510006, Guangdong, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Jiawei,Zhang, Qing,Ye, Yushan,et al. Angoline: A selective IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum[J]. PHYTOMEDICINE,2014,21(8-9):1088-1091. |
| APA | Liu, Jiawei.,Zhang, Qing.,Ye, Yushan.,Li, Wuguo.,Qiu, Junxin.,...&Yu, Qiang.(2014).Angoline: A selective IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum.PHYTOMEDICINE,21(8-9),1088-1091. |
| MLA | Liu, Jiawei,et al."Angoline: A selective IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum".PHYTOMEDICINE 21.8-9(2014):1088-1091. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。