Synthesis and Anti-Tumor Activity of Two New Water-Soluble Derivatives of Heptaplatin
文献类型：期刊论文
| 作者 | Jiang Jing1; Lou Li-Guang2 ; Chen Xi-Zhu1; Xu Yong-Ping2; Ye Qing-Song1; Liu Wei-Ping1
|
| 刊名 | CHINESE JOURNAL OF INORGANIC CHEMISTRY
 |
| 出版日期 | 2014-02-10 |
| 卷号 | 30期号:2页码:317-322 |
| 关键词 | platinum complexes synthesis anti-tumor |
| ISSN号 | 1001-4861 |
| 文献子类 | Article |
| 英文摘要 | Two water-soluble derivatives of heptaplatin, cis-[(4R,5R)-4,5-bis (aminomethyl)-2-R-1,3-dioxolane](3-hydroxy-1,1-cyclobutanedicarboxylato) platinum(II) (R=ethyl and methyl), were synthesized and characterized by elemental analysis, FAB(+)-MS and FT-IR along with C-13 NMR. They were evaluated for the cytotoxicity against three human cancer cell lines and for the antitumor activity in the murine S180 model. The results show that despite their cytotoxic potency slightly lower than that of heptaplatin, the derivatives exhibits higher antitumor activity and are worthy of further research. |
| WOS关键词 | PLATINUM(II) COMPLEXES ; CANCER ; TOXICITY ; AGENTS ; DRUGS |
| WOS研究方向 | Chemistry |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5059523 |
| WOS记录号 | WOS:000332434100013 |
| 出版者 | CHINESE CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277188]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Liu Wei-Ping |
| 作者单位 | 1.Kunming Inst Precious Met, State Key Lab Platinum Grp Met, Kunming 650106, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang Jing,Lou Li-Guang,Chen Xi-Zhu,et al. Synthesis and Anti-Tumor Activity of Two New Water-Soluble Derivatives of Heptaplatin[J]. CHINESE JOURNAL OF INORGANIC CHEMISTRY,2014,30(2):317-322. |
| APA | Jiang Jing,Lou Li-Guang,Chen Xi-Zhu,Xu Yong-Ping,Ye Qing-Song,&Liu Wei-Ping.(2014).Synthesis and Anti-Tumor Activity of Two New Water-Soluble Derivatives of Heptaplatin.CHINESE JOURNAL OF INORGANIC CHEMISTRY,30(2),317-322. |
| MLA | Jiang Jing,et al."Synthesis and Anti-Tumor Activity of Two New Water-Soluble Derivatives of Heptaplatin".CHINESE JOURNAL OF INORGANIC CHEMISTRY 30.2(2014):317-322. |
入库方式： OAI收割
来源：上海药物研究所
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