Four new diterpenoids from the roots of Euphorbia fischeriana
文献类型：期刊论文
| 作者 | Wang, Hong-Bing2; Chen, Wei2; Zhang, Ying-Ying2; Wang, Xiao-Yang1,2; Liu, Li-Ping2; Tong, Ling-Jiang3; Chen, Yi3
|
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2013-12 |
| 卷号 | 91页码:211-216 |
| 关键词 | Euphorbia fischeriana Diterpenoids Cytotoxicity |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2013.09.003 |
| 文献子类 | Article |
| 英文摘要 | Four new diterpenoids (1,4,5,9), together with 7 known diterpenoids (2,3,6-8,10,11), were isolated from the roots to Euphorbia fischeriana. On the basis of 1D and 2D NMR, HR-ESI-MS spectroscopic analysis, structures of the new compounds were elucidated as 11 beta-hydroxy-8,14-epoxy-ent-abieta-13(15)-en-16,12-olide (1), 3,20-dihydroxy-ent-1(10), 15-rosadiene (4), 3,7-dihydroxy-ent-1(10), 15-rosadiene (5), ingenol 6,7-epoxy-3-tetradecanoate (9). The compounds isolated were evaluated for their cytotoxicity against four cancer cell lines (A549, BEL7402, HCT116, and MDA-MB-231). Three ingenol diterpenoids (9-11) showed significant cytotoxicity against A549 with IC50 value of 335, 2.85, 2.88 mu g/mL, respectively. (C) 2013 Elsevier B.V. All rights reserved. |
| WOS关键词 | AROMATIC-COMPOUNDS ; FIJIAN PLANTS ; CHEMISTRY ; EBRACTEOLATA ; CONSTITUENTS ; FIDJIANA |
| 资助项目 | National Natural Science Foundation[81001369] ; National Natural Science Foundation[31170327] ; Fundamental Research Funds for the Central Universities of the People's Republic of China[2000219078] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000327574300031 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277356]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Wang, Hong-Bing |
| 作者单位 | 1.Liaoning Univ Tradit Chinese Med, Sch Pharm, Dalian 116600, Peoples R China; 2.Tongji Univ, Sch Life Sci & Technol, Shanghai 200092, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Hong-Bing,Chen, Wei,Zhang, Ying-Ying,et al. Four new diterpenoids from the roots of Euphorbia fischeriana[J]. FITOTERAPIA,2013,91:211-216. |
| APA | Wang, Hong-Bing.,Chen, Wei.,Zhang, Ying-Ying.,Wang, Xiao-Yang.,Liu, Li-Ping.,...&Chen, Yi.(2013).Four new diterpenoids from the roots of Euphorbia fischeriana.FITOTERAPIA,91,211-216. |
| MLA | Wang, Hong-Bing,et al."Four new diterpenoids from the roots of Euphorbia fischeriana".FITOTERAPIA 91(2013):211-216. |
入库方式： OAI收割
来源：上海药物研究所
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