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Grb14 as an Independent Good Prognosis Factor for Breast Cancer Patients Treated with Neoadjuvant Chemotherapy

文献类型：期刊论文

作者Huang, Ou2; Jiang, Min2; Zhang, Xi2; Xie, Zuoquan1; Chen, Xiaosong2; Wu, Jiayi2; Liu, Hongchun1; Shen, Kunwei2
刊名JAPANESE JOURNAL OF CLINICAL ONCOLOGY
出版日期2013-11
卷号43期号:11页码:1064-1072
关键词grb14 breast cancer locally advanced neoadjuvant chemotherapy prognosis
ISSN号0368-2811
DOI10.1093/jjco/hyt130
文献子类Article
英文摘要Objective: Growth factor receptor-binding protein 14, a new member of noncatalytic adaptor proteins family, has been shown to be upregulated in breast cancer. We investigated the prognostic value of growth factor receptor-binding protein 14 expression in breast cancer patients treated with neoadjuvant chemotherapy. Methods: Primary breast cancer specimens were taken from locally advanced breast cancer patients in a Phase II clinical trial of neoadjuvant chemotherapy and the expression pattern of growth factor receptor-binding protein 14 was determined by immunohistochemistry. Kaplan-Meier analysis and Cox regression model were used to assess disease-free and overall survival, according to the expression of growth factor receptor-binding protein 14 in tumor cells. Results: Our result showed that growth factor receptor-binding protein 14 was highly expressed in 23.1% of breast cancer sections, and high expression of growth factor receptor-binding protein 14 was significantly associated with better disease-free (P = 0.016, hazard ratio 0.07, 95% confidence interval 0.06-0.08) and overall survival (P = 0.004, hazard ratio 0.02, 95% confidence interval 0.02-0.03), compared with the low-expression group. Multivariate analysis indicated that high expression of growth factor receptor-binding protein 14 was an independent good prognostic factor for both disease-free (P = 0.04, hazard ratio 0.37, 95% confidence interval 0.14-0.98) and overall survival (P = 0.03, hazard ratio 0.11, 95% confidence interval 0.10-0.82). Conclusions: High expression of growth factor receptor-binding protein 14 in breast cancer cells may help to identify low-risk patients for additional therapies after neoadjuvant chemotherapy.
WOS关键词ADAPTER PROTEIN GRB14 ; RECEPTOR ; EXPRESSION ; MICROARRAY ; MODULATOR ; INSULIN ; FAMILY ; RISK
资助项目National Natural Science Foundation of China[81202087] ; National Natural Science Foundation of China[81172520] ; National Natural Science Foundation of China[81202088] ; Leading Academic Discipline Project of Shanghai Municipal Education Commission[J50208] ; Shanghai Science and Technology Committee[12ZR1446400] ; Shanghai Science and Technology Committee[12140901503] ; Shanghai Charity Cancer Research Center[00000000]
WOS研究方向Oncology
语种英语
WOS记录号WOS:000326647400002
出版者OXFORD UNIV PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/277401]  
专题药理学第一研究室
通讯作者Shen, Kunwei
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, Shanghai 200031, Peoples R China
2.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Surg, Shanghai 200025, Peoples R China;
推荐引用方式
GB/T 7714		 Huang, Ou,Jiang, Min,Zhang, Xi,et al. Grb14 as an Independent Good Prognosis Factor for Breast Cancer Patients Treated with Neoadjuvant Chemotherapy[J]. JAPANESE JOURNAL OF CLINICAL ONCOLOGY,2013,43(11):1064-1072.
APA Huang, Ou.,Jiang, Min.,Zhang, Xi.,Xie, Zuoquan.,Chen, Xiaosong.,...&Shen, Kunwei.(2013).Grb14 as an Independent Good Prognosis Factor for Breast Cancer Patients Treated with Neoadjuvant Chemotherapy.JAPANESE JOURNAL OF CLINICAL ONCOLOGY,43(11),1064-1072.
MLA Huang, Ou,et al."Grb14 as an Independent Good Prognosis Factor for Breast Cancer Patients Treated with Neoadjuvant Chemotherapy".JAPANESE JOURNAL OF CLINICAL ONCOLOGY 43.11(2013):1064-1072.

入库方式： OAI收割

来源：上海药物研究所

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